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Review
. 2019 Apr-Jun;41(2):252-265.
doi: 10.1590/2175-8239-JBN-2018-0097. Epub 2018 Nov 14.

Pediatric lupus nephritis

[Article in English, Portuguese]
Sergio Veloso Brant Pinheiro  1 , Raphael Figuiredo Dias  1 , Rafaela Cabral Gonçalves Fabiano  1 , Stanley de Almeida Araujo  1 , Ana Cristina Simões E Silva  1
Affiliations
Review

Pediatric lupus nephritis

[Article in English, Portuguese]
Sergio Veloso Brant Pinheiro et al. J Bras Nefrol. 2019 Apr-Jun.

Abstract

Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations seen in individuals with systemic lupus erythematosus (SLE). LN is more frequent and severe in pediatric patients and has been associated with higher morbidity and mortality rates. This narrative review aimed to describe the general aspects of LN and its particularities when affecting children and adolescents, while focusing on the disease's etiopathogenesis, clinical manifestations, renal tissue alterations, and treatment options.

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Figures

Figure 1
Figure 1. Schematic representation of the pathogenesis of lupus nephritis.
Figure 2
Figure 2. Characteristics and specificity of the histopathology of lupus nephritis. Adapted from Jennette et al. (1983).
Figure 3
Figure 3. Histopathology classification of lupus nephritis according to the criteria established by the International Society of Nephrology and the Renal Pathology Society (ISN/RPS) in 2003 revised in 2018,,.
See this image and copyright information in PMC

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