Trabectedin for reversing platinum resistance and resensitization to platinum in patients with recurrent ovarian cancer

Abstract

Aims: We evaluated trabectedin in patients with platinum-resistant/refractory and partially platinum-sensitive recurrent ovarian cancer and the outcomes after reintroduction of platinum.

Methods: Twenty-seven patients (platinum-resistant/refractory n = 24/PPS; n = 3) treated with trabectedin were retrospectively analyzed.

Results: Trabectedin resulted in an objective response rate (ORR) of 18.2% with a 59.1% of disease control rate (ORR plus stable disease). The median progression-free and overall survival were 3.0 and 21.3 months, respectively. Subsequently, 17 patients were retreated with platinum and yield an ORR of 41.2% and DCR of 47.0%. The median progression-free and overall survival after platinum rechallenge were 5.0 and 14.7 months, respectively.

Conclusion: Our results suggest that trabectedin may contribute to resensitize tumor cells to platinum rechallenge.

Keywords: ovarian cancer; platinum rechallenge; platinum-resistant/refractory; resensitization; trabectedin.