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. 2018 Nov 21;100(4):763-765.
doi: 10.1016/j.neuron.2018.11.011.

Unlocking the Dangers of a Stiffening Brain

Shelly Kaushik  1 , Anders I Persson  2
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Unlocking the Dangers of a Stiffening Brain

Shelly Kaushik et al. Neuron. .
Free article

Abstract

Mechanical cues regulate neuronal function and reactivity of glial cells, the origin of gliomas. In this issue of Neuron, Chen et al. (2018) uncover a feedforward loop mediated by the mechanosensitive ion channel Piezo1 and tissue stiffness that drives glioma aggression.

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