Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Feb;16(2):109-111.
doi: 10.1038/s41423-018-0180-2. Epub 2018 Nov 22.

Neuroendocrine control of natural killer cell function through the checkpoint molecule PD-1

Justine Devulder  1   2   3   4 , Anne Tsicopoulos  1   2   3   4   5 , Catherine Duez  6   7   8   9
Affiliations
Comment

Neuroendocrine control of natural killer cell function through the checkpoint molecule PD-1

Justine Devulder et al. Cell Mol Immunol. 2019 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Regulation of spleen immunopathology by NK cells during MCMV infection involves HPA-GC-PD-1 axis.
HPA axis is activated during MCMV infection and increases GC production. In conjunction with cytokine microenvironment of the spleen, GC upregulates PD-1 expression on NK cells, responsible for decreased expression of IFN-γ leading to decreased immunopathology. The place of SNS and other stress hormones capable of regulating NK cells has yet to be studied. Severe and chronic stress is associated with hypertrophy of adrenal cortex and reduced sensitivity of HPA axis to negative feedback. Hence chronic stressors can affect susceptibility to infection through GC mediated suppression of immune responses. Therefore, chronic stress, but also clock control of GC secretion, and bacterial secondary infection may complicate the picture. CRH corticotropin-releasing hormone, ACTH adrenocorticotropic hormone, GC glucocorticoid (cortisol in human, corticosterone in rodent), SNS sympathetic nervous system, NE norepinephrine, E epinephrine, PNMT phenylethanolamine-N-methyltransferase, NK natural killer
See this image and copyright information in PMC

Comment on

References

    1. Medzhitov R, Schneider DS, Soares MP. Disease tolerance as a defense strategy. Sci. 2012;335:936–941. doi: 10.1126/science.1214935. - DOI - PMC - PubMed
    1. Soares MP, Teixeira L, Moita LF. Disease tolerance and immunity in host protection against infection. Nat. Rev. Immunol. 2017;17:83–96. doi: 10.1038/nri.2016.136. - DOI - PubMed
    1. ThyagaRajan S, Priyanka HP. Bidirectional communication between the neuroendocrine system and the immune system: relevance to health and diseases. Ann. Neurosci. janv. 2012;19:40–46. - PMC - PubMed
    1. Mn Silverman, Bd Pearce, Ca Biron, Ah Miller. Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection. Viral Immunol. 2005;18:41–78. doi: 10.1089/vim.2005.18.41. - DOI - PMC - PubMed
    1. Bailey M, Engler H, Hunzeker J, Sheridan JF. The hypothalamic-pituitary-adrenal axis and viral infection. Viral Immunol. 2003;16:141–157. doi: 10.1089/088282403322017884. - DOI - PubMed