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. 2018 Dec 6;54(98):13833-13836.
doi: 10.1039/c8cc08238c.

Hydride transfer initiated ring expansion of pyrrolidines toward highly functionalized tetrahydro-1-benzazepines

Shuai Wang  1 , Xiao-De An, Shuai-Shuai Li, Xicheng Liu, Qing Liu, Jian Xiao
Affiliations

Hydride transfer initiated ring expansion of pyrrolidines toward highly functionalized tetrahydro-1-benzazepines

Shuai Wang et al. Chem Commun (Camb). .

Abstract

A novel hydride transfer initiated ring expansion of 4-pyrrolidinyl isatins to synthesize tetrahydro-1-benzazepines has been developed. This methodology represents an atom- and step-economical protocol to assemble seven-membered polycyclic amines from pyrrolidine derivatives in one step.

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