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. 2019 Apr;185(1):128-132.
doi: 10.1111/bjh.15687. Epub 2018 Nov 22.

Cancer specific survival in patients with sickle cell disease

Ann Brunson  1 , Theresa H M Keegan  1 , Anjlee Mahajan  1 , Susan Paulukonis  2 , Ted Wun  1   3
Affiliations

Cancer specific survival in patients with sickle cell disease

Ann Brunson et al. Br J Haematol. 2019 Apr.

Abstract

Sickle cell disease (SCD) patients have a higher incidence of certain cancers, but no studies have determined the impact of cancer on survival among SCD patients. SCD patients (n = 6423), identified from state-wide hospitalisation data, were linked to the California Cancer Registry (1988-2014). Multivariable Cox proportional hazards regression was used to examine survival. Among SCD patients, a cancer diagnosis was associated with a 3-fold increased hazard of death. Compared to matched cancer patients without SCD, SCD was associated with worse overall survival, but not cancer-specific survival, suggesting that SCD cancer patients should be treated with similar therapeutic intent.

Keywords: Sickle cell disease; cancer; epidemiology; survival.

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Figures

Figure 1—
Figure 1—
Overall and cancer-specific survival among cancer patients with sickle cell disease matched to cancer patients without sickle cell disease.
See this image and copyright information in PMC

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