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Review
. 2018 Dec;52(11-12):1210-1219.
doi: 10.1080/10715762.2018.1516285. Epub 2018 Nov 23.

The role of decorin in cardiovascular diseases: more than just a decoration

Thu Thi Vu  1 , Jubert Marquez  2   3 , Long Thanh Le  2   3 , Anh Thi Tuyet Nguyen  2   3 , Hyoung Kyu Kim  2   3   4 , Jin Han  2   3
Affiliations
Review

The role of decorin in cardiovascular diseases: more than just a decoration

Thu Thi Vu et al. Free Radic Res. 2018 Dec.

Abstract

Decorin (DCN) is a proteoglycan constituent of the extracellular matrix (ECM) possessing powerful antifibrotic, anti-inflammation, antioxidant, and antiangiogenic properties. By attaching to receptors in the cell surface or to several ECM molecules, it regulates plenty of cellular functions, consequently influencing cell differentiation, proliferation, and apoptosis. These processes are dependent on cell types, biological contexts, and interfere with pathological processes such as cardiovascular diseases. In this review, we briefly discuss the potential of DCN targeting in addressing cardiovascular diseases (CVD). We dive into its interactome and discuss how its interaction with the proteins can affect disease progression, and how DCN can be a possible target for CVD therapeutics.

Keywords: Cardiovascular disease; decorin; heart failure; mitochondria.

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