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Review
. 2018 Nov 22;19(12):3703.
doi: 10.3390/ijms19123703.

Fish, Fish Oils and Cardioprotection: Promise or Fish Tale?

Akshay Goel  1 , Naga Venkata Pothineni  2 , Mayank Singhal  3 , Hakan Paydak  4 , Tom Saldeen  5 , Jawahar L Mehta  6
Affiliations
Review

Fish, Fish Oils and Cardioprotection: Promise or Fish Tale?

Akshay Goel et al. Int J Mol Sci. .

Abstract

Fish and commercially available fish oil preparations are rich sources of long-chain omega-3 polyunsaturated fatty acids. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the most important fatty acids in fish oil. Following dietary intake, these fatty acids get incorporated into the cell membrane phospholipids throughout the body, especially in the heart and brain. They play an important role in early brain development during infancy, and have also been shown to be of benefit in dementia, depression, and other neuropsychiatric disorders. Early epidemiologic studies show an inverse relationship between fish consumption and the risk of coronary heart disease. This led to the identification of the cardioprotective role of these marine-derived fatty acids. Many experimental studies and some clinical trials have documented the benefits of fish oil supplementation in decreasing the incidence and progression of atherosclerosis, myocardial infarction, heart failure, arrhythmias, and stroke. Possible mechanisms include reduction in triglycerides, alteration in membrane fluidity, modulation of cardiac ion channels, and anti-inflammatory, anti-thrombotic, and anti-arrhythmic effects. Fish oil supplements are generally safe, and the risk of toxicity with methylmercury, an environmental toxin found in fish, is minimal. Current guidelines recommend the consumption of either one to two servings of oily fish per week or daily fish oil supplements (around 1 g of omega-3 polyunsaturated fatty acids per day) in adults. However, recent large-scale studies have failed to demonstrate any benefit of fish oil supplements on cardiovascular outcomes and mortality. Here, we review the different trials that evaluated the role of fish oil in cardiovascular diseases.

Keywords: cardiovascular disease; docosahexaenoic acid (DHA); eicosapentaenoic acid (EPA); fish oil; omega-3 fatty acids.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Structure and metabolism of major polyunsaturated fatty acids (PUFAs).
Figure 2
Figure 2
Pleiotropic cardioprotective effects of ω-3 PUFAs.
See this image and copyright information in PMC

References

    1. Bauer U.E., Briss P.A., Goodman R.A., Bowman B.A. Prevention of chronic disease in the 21st century: Elimination of the leading preventable causes of premature death and disability in the USA. Lancet. 2014;384:45–52. doi: 10.1016/S0140-6736(14)60648-6. - DOI - PubMed
    1. Bang H.O., Dyerberg J., Nielsen A. Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet. 1971;297:1143–1146. doi: 10.1016/S0140-6736(71)91658-8. - DOI - PubMed
    1. Bang H.O., Dyerberg J., Sinclair H.M. The composition of the Eskimo food in north western Greenland. Am. J. Clin. Nutr. 1980;33:2657–2661. doi: 10.1093/ajcn/33.12.2657. - DOI - PubMed
    1. Burr M.L., Gilbert J.F., Holliday R.A., Elwood P.C., Fehily A.M., Rogers S., Sweetnam P.M., Deadman N.M. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and reinfarction trial (DART) Lancet. 1989;334:757–761. doi: 10.1016/S0140-6736(89)90828-3. - DOI - PubMed
    1. Yang B., Saldeen T.G., Nichols W.W., Mehta J.L. Dietary fish oil supplementation attenuates myocardial dysfunction and injury caused by global ischemia and reperfusion in isolated rat hearts. J. Nutr. 1993;123:2067–2074. - PubMed

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