Association between dementia and mortality in the elderly patients undergoing hip fracture surgery: a meta-analysis

doi:10.1186/s13018-018-0988-6

Meta-Analysis

. 2018 Nov 23;13(1):298.

doi: 10.1186/s13018-018-0988-6.

Association between dementia and mortality in the elderly patients undergoing hip fracture surgery: a meta-analysis

Jianzhong Bai¹, Pei Zhang¹, Xinyu Liang¹, Zhipeng Wu², Jingcheng Wang³, Yuan Liang⁴

Affiliations

¹ Dalian Medical University, Dalian, 116044, Liaoning, China.
² The second XiangYa hospital, Central South University, Changsha, 410011, China.
³ Clinical Medical College of Yangzhou University, Yangzhou, 225001, China. wangjcyangzhou@163.com.
⁴ Clinical Medical College of Yangzhou University, Yangzhou, 225001, China. 464156241@qq.com.

PMID: 30470251
PMCID: PMC6260652
DOI: 10.1186/s13018-018-0988-6

Meta-Analysis

Association between dementia and mortality in the elderly patients undergoing hip fracture surgery: a meta-analysis

Jianzhong Bai et al. J Orthop Surg Res. 2018.

. 2018 Nov 23;13(1):298.

doi: 10.1186/s13018-018-0988-6.

Authors

Jianzhong Bai¹, Pei Zhang¹, Xinyu Liang¹, Zhipeng Wu², Jingcheng Wang³, Yuan Liang⁴

Affiliations

¹ Dalian Medical University, Dalian, 116044, Liaoning, China.
² The second XiangYa hospital, Central South University, Changsha, 410011, China.
³ Clinical Medical College of Yangzhou University, Yangzhou, 225001, China. wangjcyangzhou@163.com.
⁴ Clinical Medical College of Yangzhou University, Yangzhou, 225001, China. 464156241@qq.com.

PMID: 30470251
PMCID: PMC6260652
DOI: 10.1186/s13018-018-0988-6

Abstract

Objective: This study was designed to verify the association between dementia and mortality in the elderly undergoing hip fracture surgery, and assessed the mortality of patients with dementia after hip fracture surgery.

Material and methods: PubMed, Embase, and Web of Science were searched until April, 2018 without language restrictions. Two reviewers selected related studies, assessed study quality, and extracted data independently. Risk ratios (RRs) with 95% confidence intervals (CI) were derived using random-effects model throughout all analyses. The endpoints included 30-day, 6-month, 1-year, and more than 1-year mortality. This meta-analysis was performed following PRISMA statement and carried out by using stata14.0 software.

Results: Dementia significantly increased postoperative mortality of patients suffered from hip fracture in 30-day [RR = 1.57, 95% CI (1.29, 1.90), P<0.00], 6-month [RR = 1.97, 95% CI (1.47, 2.63), P<0.00], 1-year [RR = 1.77, 95% CI (1.54, 2.04), P<0.00], and more than 1-year follow up [RR = 1.60, 95% CI (1.30, 1.96), P<0.00] respectively. The mortality of dementia patients after hip fracture surgery in 30-day [ES = 12%, 95% CI (8%, 15%)], 6-month [ES = 32%, 95% CI (17%, 48%)], 1-year [ES = 39%, 95% CI (35%, 43%)], and more than 1-year follow up [ES = 45%, 95% CI (32%, 58%)].

Conclusions: Our meta-analysis demonstrated that the mortality of patients with dementia suffered from hip fracture surgery is 12%, 32%, 39%, and 45%, and dementia increased 1.57, 1.97, 1.77, and 1.60-fold mortality in patients undergoing hip fracture surgery in 30-day, 6-month, 1-year, and more than 1-year follow up respectively.

Keywords: Dementia; Hip fracture; Meta-analysis; Mortality.

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Ethics approval and consent to participate

All analyses were based on previously published studies; thus, no ethical approval and patient consent are required.

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Figures

**Fig. 1**
The flow chart of studies selecting

**Fig. 2**
The effect of dementia on the mortality of patients after hip fracture surgery

**Fig. 3**
The mortality of dementia patients after hip fracture surgery

See this image and copyright information in PMC

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References

1. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9(1):63–75.e62. doi: 10.1016/j.jalz.2012.11.007. - DOI - PubMed
1. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336–341. doi: 10.1016/j.ijsu.2010.02.007. - DOI - PubMed
1. Higgins J, Green S: Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. Cochrane Collab 2011. Available at: www.handbook.cochrane.org. Accessed 24 Apr 2016.
1. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–605. doi: 10.1007/s10654-010-9491-z. - DOI - PubMed
1. Gu WJ, Wu XD, Zhou Q, et al. Relationship between annualized case volume and mortality in sepsis: a dose-response meta-analysis. Anesthesiology. 2016;125(1):168–179. doi: 10.1097/ALN.0000000000001133. - DOI - PubMed

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[1] Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9(1):63–75.e62. doi: 10.1016/j.jalz.2012.11.007. - DOI - PubMed

[2] Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9(1):63–75.e62. doi: 10.1016/j.jalz.2012.11.007. - DOI - PubMed

[3] Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336–341. doi: 10.1016/j.ijsu.2010.02.007. - DOI - PubMed

[4] Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336–341. doi: 10.1016/j.ijsu.2010.02.007. - DOI - PubMed

[5] Higgins J, Green S: Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. Cochrane Collab 2011. Available at: www.handbook.cochrane.org. Accessed 24 Apr 2016.

[6] Higgins J, Green S: Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. Cochrane Collab 2011. Available at: www.handbook.cochrane.org. Accessed 24 Apr 2016.

[7] Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–605. doi: 10.1007/s10654-010-9491-z. - DOI - PubMed

[8] Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–605. doi: 10.1007/s10654-010-9491-z. - DOI - PubMed

[9] Gu WJ, Wu XD, Zhou Q, et al. Relationship between annualized case volume and mortality in sepsis: a dose-response meta-analysis. Anesthesiology. 2016;125(1):168–179. doi: 10.1097/ALN.0000000000001133. - DOI - PubMed

[10] Gu WJ, Wu XD, Zhou Q, et al. Relationship between annualized case volume and mortality in sepsis: a dose-response meta-analysis. Anesthesiology. 2016;125(1):168–179. doi: 10.1097/ALN.0000000000001133. - DOI - PubMed

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