Management of Demyelinating Disorders in Pregnancy

Abstract

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are chronic inflammatory demyelinating disorders of the central nervous system that often affect women during childbearing years. Therefore, issues of conception, pregnancy, and delivery are of significant importance to patients and treating physicians. The current review provides updated information regarding the effects of pregnancy on MS and NMO, as well as the available safety data on immunomodulatory MS therapies for pregnant and lactating women. Management issues of women with MS and NMO during conception, gestation, and the postpartum period also are addressed.

Keywords: Demyelinating disease; Disease-modifying therapy; Lactation; Multiple sclerosis; Neuromyelitis optica; Pregnancy; Relapse.