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Comment
. 2018 Dec;4(12):798-801.
doi: 10.1016/j.trecan.2018.10.009. Epub 2018 Nov 9.

Regulators of Asymmetric Cell Division in Breast Cancer

Jiannis Ragoussis  1
Affiliations
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Regulators of Asymmetric Cell Division in Breast Cancer

Jiannis Ragoussis. Trends Cancer. 2018 Dec.

Abstract

The aggressive triple-negative breast cancer (TNBC) pathological group poses significant challenges for both diagnosis and treatment because high levels of cellular heterogeneity are one of its hallmarks. In a recent issue of Cell Reports, Granit et al. shed light into how regulation of asymmetric cell division contributes to heterogeneity in TNBC, and identify key control factors. With the help of technological advances, deeper understanding of these processes will lead to new cancer therapeutics.

Keywords: FOXA1; NOTCH; asymmetric cell division; breast cancer.

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