Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan;30(1):35-42.
doi: 10.1016/j.nec.2018.08.002. Epub 2018 Nov 1.

Clinical Presentation, Natural History, and Prognosis of Diffuse Low-Grade Gliomas

Anja Smits  1 , Asgeir S Jakola  2
Affiliations
Review

Clinical Presentation, Natural History, and Prognosis of Diffuse Low-Grade Gliomas

Anja Smits et al. Neurosurg Clin N Am. 2019 Jan.

Abstract

Diffuse low-grade gliomas (DLGGs) are primary brain tumors characterized by slow growth but extensive infiltration into the surrounding brain. Patients are typically 30 to 40 years at disease onset and present with focal or focal to bilateral tonic-clonic seizures. The tumor will transform into a malignant glioma and eventually lead to death, but after varying lengths of time. The specific features of DLGG impose a major challenge to decide optimal treatment strategies and timing of treatment, while maintaining patients' quality of life. We discuss the clinical challenges at disease onset with regard to the natural history and long-term prognosis.

Keywords: Diffuse low-grade gliomas; Natural history; Prognosis; Symptoms.

PubMed Disclaimer