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Review
. 2019 Jan;30(1):43-54.
doi: 10.1016/j.nec.2018.09.001. Epub 2018 Nov 1.

Diffuse Low-Grade Glioma-Related Epilepsy

Johan Pallud  1 , Guy M McKhann  2
Affiliations
Review

Diffuse Low-Grade Glioma-Related Epilepsy

Johan Pallud et al. Neurosurg Clin N Am. 2019 Jan.

Abstract

The World Health Organization classifies diffuse low-grade gliomas (DLGGs) are highly epileptogenic primary brain tumors; epileptic seizures occur in more than 90% of cases. Epileptic seizures and drug resistance progress during the course of DLGGs. The glioma-related epileptogenic mechanisms are multifactorial; epileptogenic foci lie within the infiltrated peritumoral neocortex. A short seizure duration before surgery and a large extent of resection are the main predictors of postoperative seizure control in DLGGs. A supratotal resection of a DLGG can improve postoperative seizure control. Epileptic seizure at diagnosis positively affects DLGGs malignant transformation and overall survival.

Keywords: Diffuse low-grade glioma; Epileptic seizure; GABA; Glutamate; Isocitrate dehydrogenase; Mammalian target of rapamycin (mTOR); Maximal functional-based resection; Surgery.

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