Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

Theo G M van Erp¹, Esther Walton², Derrek P Hibar³, Lianne Schmaal⁴, Wenhao Jiang⁵, David C Glahn⁶, Godfrey D Pearlson⁶, Nailin Yao⁶, Masaki Fukunaga⁷, Ryota Hashimoto⁸, Naohiro Okada⁹, Hidenaga Yamamori¹⁰, Vincent P Clark¹¹, Bryon A Mueller¹², Sonja M C de Zwarte¹³, Roel A Ophoff¹⁴, Neeltje E M van Haren¹⁵, Ole A Andreassen¹⁶, Tiril P Gurholt¹⁷, Oliver Gruber¹⁸, Bernd Kraemer¹⁹, Anja Richter¹⁹, Vince D Calhoun¹¹, Benedicto Crespo-Facorro²⁰, Roberto Roiz-Santiañez²⁰, Diana Tordesillas-Gutiérrez²¹, Carmel Loughland²², Stanley Catts²³, Janice M Fullerton²⁴, Melissa J Green²⁵, Frans Henskens²⁶, Assen Jablensky²⁷, Bryan J Mowry²⁸, Christos Pantelis²⁹, Yann Quidé²⁵, Ulrich Schall³⁰, Rodney J Scott³¹, Murray J Cairns³¹, Marc Seal³², Paul A Tooney³³, Paul E Rasser³⁴, Gavin Cooper³⁴, Cynthia Shannon Weickert³⁵, Thomas W Weickert²⁵, Elliot Hong³⁶, Peter Kochunov³⁶, Raquel E Gur³⁷, Ruben C Gur³⁷, Judith M Ford³⁸, Fabio Macciardi³⁹, Daniel H Mathalon³⁸, Steven G Potkin³⁹, Adrian Preda³⁹, Fengmei Fan⁴⁰, Stefan Ehrlich⁴¹, Margaret D King⁴², Lieuwe De Haan⁴³, Dick J Veltman⁴⁴, Francesca Assogna⁴⁵, Nerisa Banaj⁴⁶, Pietro de Rossi⁴⁷, Mariangela Iorio⁴⁶, Fabrizio Piras⁴⁵, Gianfranco Spalletta⁴⁸, Edith Pomarol-Clotet⁴⁹, Sinead Kelly⁵⁰, Simone Ciufolini⁵¹, Joaquim Radua⁵², Robin Murray⁵¹, Tiago Reis Marques⁵¹, Andrew Simmons⁵¹, Stefan Borgwardt⁵³, Fabienne Schönborn-Harrisberger⁵³, Anita Riecher-Rössler⁵³, Renata Smieskova⁵³, Kathryn I Alpert⁵⁴, Alessandro Bertolino⁵⁵, Aurora Bonvino⁵⁶, Annabella Di Giorgio⁵⁶, Emma Neilson⁵⁷, Andrew R Mayer⁴², Je-Yeon Yun⁵⁸, Dara M Cannon⁵⁹, Irina Lebedeva⁶⁰, Alexander S Tomyshev⁶⁰, Tolibjohn Akhadov⁶¹, Vasily Kaleda⁶⁰, Helena Fatouros-Bergman⁶², Lena Flyckt⁶²; Karolinska Schizophrenia Project; Pedro G P Rosa⁶³, Mauricio H Serpa⁶³, Marcus V Zanetti⁶³, Cyril Hoschl⁶⁴, Antonin Skoch⁶⁵, Filip Spaniel⁶⁴, David Tomecek⁶⁶, Andrew M McIntosh⁶⁷, Heather C Whalley⁵⁷, Christian Knöchel⁶⁸, Viola Oertel-Knöchel⁶⁸, Fleur M Howells⁶⁹, Dan J Stein⁷⁰, Henk S Temmingh⁶⁹, Anne Uhlmann⁷¹, Carlos Lopez-Jaramillo⁷², Danai Dima⁷³, Joshua I Faskowitz⁷⁴, Boris A Gutman⁷⁵, Neda Jahanshad⁷⁴, Paul M Thompson⁷⁴, Jessica A Turner⁷⁶

Collaborators, Affiliations

Collaborators

Karolinska Schizophrenia Project:
Lars Farde, Lena Flyckt, Helena Fatouros-Bergman, Simon Cervenka, Ingrid Agartz, Karin Collste, Pauliina Victorsson, Göran Engberg, Sophie Erhardt, Lilly Schwieler, Anna Malmqvist, Mikael Hedberg, Funda Orhan, Fredrik Piehl, Ingrid Agartz

Affiliations

¹ Department of Psychiatry and Human Behavior, University of California, Irvine, California. Electronic address: tvanerp@uci.edu.
² Medical Research Council Integrative Epidemiology Unit and Bristol Medical School, Population Health Sciences, University of Bristol, United Kingdom.
³ Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California; Janssen Research and Development, San Diego, California.
⁴ Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia; Centre for Youth Mental Health, The University of Melbourne, Victoria, Australia; Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
⁵ Department of Psychology, Georgia State University, Atlanta, Georgia.
⁶ Department of Psychiatry, Yale University, New Haven, Connecticut; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut.
⁷ Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.
⁸ Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan; Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Osaka, Japan.
⁹ Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
¹⁰ Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
¹¹ University of New Mexico, Albuquerque, New Mexico; Mind Research Network, Albuquerque, New Mexico.
¹² Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
¹³ Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁴ University of California Los Angeles Center for Neurobehavioral Genetics, Los Angeles, California.
¹⁵ Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre, Rotterdam, The Netherlands.
¹⁶ Norwegian Centre for Mental Disorders Research, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Norwegian Centre for Mental Disorders Research, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway.
¹⁷ Norwegian Centre for Mental Disorders Research, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Norwegian Centre for Mental Disorders Research, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
¹⁸ Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
¹⁹ Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Göttingen, Germany.
²⁰ Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-Valdecilla Biomedical Research Institute, Marqués de Valdecilla Research Institute, Santander, Spain; Centro Investigación Biomédica en Red de Salud Mental, Santander, Spain.
²¹ Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-Valdecilla Biomedical Research Institute, Marqués de Valdecilla Research Institute, Santander, Spain; Centro Investigación Biomédica en Red de Salud Mental, Santander, Spain; Neuroimaging Unit Technological Facilities, Valdecilla Biomedical Research Institute, Santander, Cantabria, Spain.
²² Hunter Medical Research Institute, New South Wales, Australia; Priority Research Centre for Brain and Mental Health, The University of Newcastle, New South Wales, Australia; Hunter New England Local Health District, Newcastle, New South Wales, Australia.
²³ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; University of Queensland, Brisbane, Queensland, Australia.
²⁴ Neuroscience Research Australia, Sydney, New South Wales, Australia; School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
²⁵ Neuroscience Research Australia, Sydney, New South Wales, Australia; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
²⁶ Hunter Medical Research Institute, New South Wales, Australia; Priority Research Center for Health Behaviour, The University of Newcastle, New South Wales, Australia; School of Medicine and Public Health, The University of Newcastle, New South Wales, Australia.
²⁷ University of Western Australia, Perth, Western Australia, Australia.
²⁸ Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland, Australia.
²⁹ Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.
³⁰ Priority Research Centres for Brain and Mental Health and Grow Up Well, The University of Newcastle, New South Wales, Australia.
³¹ Hunter Medical Research Institute, New South Wales, Australia; School of Biomedical Sciences and Pharmacy, The University of Newcastle, New South Wales, Australia.
³² Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
³³ Hunter Medical Research Institute, New South Wales, Australia; Priority Research Centre for Brain and Mental Health, The University of Newcastle, New South Wales, Australia; School of Biomedical Sciences and Pharmacy, The University of Newcastle, New South Wales, Australia.
³⁴ Priority Research Centre for Brain and Mental Health, The University of Newcastle, New South Wales, Australia.
³⁵ Neuroscience Research Australia, Sydney, New South Wales, Australia; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia; Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York.
³⁶ Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland.
³⁷ Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania.
³⁸ Department of Psychiatry, University of California, San Francisco, California; San Francisco Veterans Affairs Medical Center, San Francisco, California.
³⁹ Department of Psychiatry and Human Behavior, University of California, Irvine, California.
⁴⁰ Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.
⁴¹ Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany; Massachusetts General Hospital/Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Psychiatric Neuroimaging Research Program, Boston, Massachusetts.
⁴² Mind Research Network, Albuquerque, New Mexico.
⁴³ Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
⁴⁴ Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
⁴⁵ Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto Di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy; Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche "Enrico Fermi," Rome, Italy.
⁴⁶ Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto Di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy.
⁴⁷ Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto Di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy; Dipartimento di Neuroscienze, Salute Mentale e Organi di Senso Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy; Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
⁴⁸ Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto Di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas.
⁴⁹ Fundación para la Investigación y Docencia Maria Angustias Giménez Germanes Hospitalaries Research Foundation, Barcelona, Spain.
⁵⁰ Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
⁵¹ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
⁵² Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Fundación para la Investigación y Docencia Maria Angustias Giménez Germanes Hospitalaries Research Foundation, Barcelona, Spain; Centro Investigación Biomédica en Red de Salud Mental, Barcelona, Spain; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden; Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
⁵³ University of Basel Psychiatric Hospital, Basel, Switzerland.
⁵⁴ Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁵⁵ Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari "Aldo Moro," Bari, Italy.
⁵⁶ Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
⁵⁷ Division of Psychiatry, University of Edinburgh, United Kingdom.
⁵⁸ Seoul National University Hospital, Seoul, Republic of Korea; Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
⁵⁹ Centre for Neuroimaging and Cognitive Genomics, Clinical Neuroimaging Laboratory, National Centre for Biomedical Engineering Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
⁶⁰ Mental Health Research Center, Moscow, Russia.
⁶¹ Children's Clinical and Research Institute of Emergency Surgery and Trauma, Moscow, Russia.
⁶² Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm County Council, and the Karolinska Schizophrenia Project, Stockholm, Sweden.
⁶³ Laboratory of Psychiatric Neuroimaging, Department of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil; Center for Interdisciplinary Research on Applied Neurosciences, University of São Paulo, São Paulo, Brazil.
⁶⁴ National Institute of Mental Health, Klecany, Czech Republic.
⁶⁵ National Institute of Mental Health, Klecany, Czech Republic; Magnetic Resonance Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
⁶⁶ National Institute of Mental Health, Klecany, Czech Republic; Institute of Computer Science, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
⁶⁷ Division of Psychiatry, University of Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom.
⁶⁸ Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.
⁶⁹ Department of Psychiatry, Groote Schuur Hospital, Stellenbosch University, Cape Town, South Africa.
⁷⁰ Department of Psychiatry, Groote Schuur Hospital, Stellenbosch University, Cape Town, South Africa; Medical Research Council Unit on Risk & Resilience in Mental Disorders, Stellenbosch University, Cape Town, South Africa.
⁷¹ Department of Psychiatry, Groote Schuur Hospital, Stellenbosch University, Cape Town, South Africa; Department of Psychiatry, MRC Unit on Risk & Resilience in Mental Disorders, Stellenbosch University, Cape Town, South Africa.
⁷² Research Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.
⁷³ Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Department of Psychology, City, University of London, London, United Kingdom.
⁷⁴ Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California.
⁷⁵ Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois.
⁷⁶ Imaging Genetics and Neuroinformatics Laboratory, Department of Psychology, Georgia State University, Atlanta, Georgia; Mind Research Network, Albuquerque, New Mexico.

PMID: 30470561
PMCID: PMC7041557
DOI: 10.1016/j.biopsych.2018.10.003

Comment

Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

Theo G M van Erp et al. Biol Psychiatry. 2019.

. 2019 Apr 1;85(7):e35-e39.

doi: 10.1016/j.biopsych.2018.10.003. Epub 2018 Nov 22.

Authors

Collaborators

Karolinska Schizophrenia Project:
Lars Farde, Lena Flyckt, Helena Fatouros-Bergman, Simon Cervenka, Ingrid Agartz, Karin Collste, Pauliina Victorsson, Göran Engberg, Sophie Erhardt, Lilly Schwieler, Anna Malmqvist, Mikael Hedberg, Funda Orhan, Fredrik Piehl, Ingrid Agartz

Affiliations

¹ Department of Psychiatry and Human Behavior, University of California, Irvine, California. Electronic address: tvanerp@uci.edu.
² Medical Research Council Integrative Epidemiology Unit and Bristol Medical School, Population Health Sciences, University of Bristol, United Kingdom.
³ Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California; Janssen Research and Development, San Diego, California.
⁴ Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia; Centre for Youth Mental Health, The University of Melbourne, Victoria, Australia; Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
⁵ Department of Psychology, Georgia State University, Atlanta, Georgia.
⁶ Department of Psychiatry, Yale University, New Haven, Connecticut; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut.
⁷ Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.
⁸ Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan; Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Osaka, Japan.
⁹ Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
¹⁰ Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
¹¹ University of New Mexico, Albuquerque, New Mexico; Mind Research Network, Albuquerque, New Mexico.
¹² Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
¹³ Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁴ University of California Los Angeles Center for Neurobehavioral Genetics, Los Angeles, California.
¹⁵ Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre, Rotterdam, The Netherlands.
¹⁶ Norwegian Centre for Mental Disorders Research, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Norwegian Centre for Mental Disorders Research, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway.
¹⁷ Norwegian Centre for Mental Disorders Research, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Norwegian Centre for Mental Disorders Research, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
¹⁸ Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
¹⁹ Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Göttingen, Germany.
²⁰ Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-Valdecilla Biomedical Research Institute, Marqués de Valdecilla Research Institute, Santander, Spain; Centro Investigación Biomédica en Red de Salud Mental, Santander, Spain.
²¹ Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-Valdecilla Biomedical Research Institute, Marqués de Valdecilla Research Institute, Santander, Spain; Centro Investigación Biomédica en Red de Salud Mental, Santander, Spain; Neuroimaging Unit Technological Facilities, Valdecilla Biomedical Research Institute, Santander, Cantabria, Spain.
²² Hunter Medical Research Institute, New South Wales, Australia; Priority Research Centre for Brain and Mental Health, The University of Newcastle, New South Wales, Australia; Hunter New England Local Health District, Newcastle, New South Wales, Australia.
²³ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; University of Queensland, Brisbane, Queensland, Australia.
²⁴ Neuroscience Research Australia, Sydney, New South Wales, Australia; School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
²⁵ Neuroscience Research Australia, Sydney, New South Wales, Australia; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
²⁶ Hunter Medical Research Institute, New South Wales, Australia; Priority Research Center for Health Behaviour, The University of Newcastle, New South Wales, Australia; School of Medicine and Public Health, The University of Newcastle, New South Wales, Australia.
²⁷ University of Western Australia, Perth, Western Australia, Australia.
²⁸ Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland, Australia.
²⁹ Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.
³⁰ Priority Research Centres for Brain and Mental Health and Grow Up Well, The University of Newcastle, New South Wales, Australia.
³¹ Hunter Medical Research Institute, New South Wales, Australia; School of Biomedical Sciences and Pharmacy, The University of Newcastle, New South Wales, Australia.
³² Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
³³ Hunter Medical Research Institute, New South Wales, Australia; Priority Research Centre for Brain and Mental Health, The University of Newcastle, New South Wales, Australia; School of Biomedical Sciences and Pharmacy, The University of Newcastle, New South Wales, Australia.
³⁴ Priority Research Centre for Brain and Mental Health, The University of Newcastle, New South Wales, Australia.
³⁵ Neuroscience Research Australia, Sydney, New South Wales, Australia; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia; Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York.
³⁶ Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland.
³⁷ Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania.
³⁸ Department of Psychiatry, University of California, San Francisco, California; San Francisco Veterans Affairs Medical Center, San Francisco, California.
³⁹ Department of Psychiatry and Human Behavior, University of California, Irvine, California.
⁴⁰ Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.
⁴¹ Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany; Massachusetts General Hospital/Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Psychiatric Neuroimaging Research Program, Boston, Massachusetts.
⁴² Mind Research Network, Albuquerque, New Mexico.
⁴³ Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
⁴⁴ Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
⁴⁵ Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto Di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy; Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche "Enrico Fermi," Rome, Italy.
⁴⁶ Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto Di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy.
⁴⁷ Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto Di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy; Dipartimento di Neuroscienze, Salute Mentale e Organi di Senso Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy; Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
⁴⁸ Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto Di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas.
⁴⁹ Fundación para la Investigación y Docencia Maria Angustias Giménez Germanes Hospitalaries Research Foundation, Barcelona, Spain.
⁵⁰ Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
⁵¹ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
⁵² Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Fundación para la Investigación y Docencia Maria Angustias Giménez Germanes Hospitalaries Research Foundation, Barcelona, Spain; Centro Investigación Biomédica en Red de Salud Mental, Barcelona, Spain; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden; Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
⁵³ University of Basel Psychiatric Hospital, Basel, Switzerland.
⁵⁴ Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁵⁵ Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari "Aldo Moro," Bari, Italy.
⁵⁶ Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
⁵⁷ Division of Psychiatry, University of Edinburgh, United Kingdom.
⁵⁸ Seoul National University Hospital, Seoul, Republic of Korea; Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
⁵⁹ Centre for Neuroimaging and Cognitive Genomics, Clinical Neuroimaging Laboratory, National Centre for Biomedical Engineering Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
⁶⁰ Mental Health Research Center, Moscow, Russia.
⁶¹ Children's Clinical and Research Institute of Emergency Surgery and Trauma, Moscow, Russia.
⁶² Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm County Council, and the Karolinska Schizophrenia Project, Stockholm, Sweden.
⁶³ Laboratory of Psychiatric Neuroimaging, Department of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil; Center for Interdisciplinary Research on Applied Neurosciences, University of São Paulo, São Paulo, Brazil.
⁶⁴ National Institute of Mental Health, Klecany, Czech Republic.
⁶⁵ National Institute of Mental Health, Klecany, Czech Republic; Magnetic Resonance Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
⁶⁶ National Institute of Mental Health, Klecany, Czech Republic; Institute of Computer Science, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
⁶⁷ Division of Psychiatry, University of Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom.
⁶⁸ Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.
⁶⁹ Department of Psychiatry, Groote Schuur Hospital, Stellenbosch University, Cape Town, South Africa.
⁷⁰ Department of Psychiatry, Groote Schuur Hospital, Stellenbosch University, Cape Town, South Africa; Medical Research Council Unit on Risk & Resilience in Mental Disorders, Stellenbosch University, Cape Town, South Africa.
⁷¹ Department of Psychiatry, Groote Schuur Hospital, Stellenbosch University, Cape Town, South Africa; Department of Psychiatry, MRC Unit on Risk & Resilience in Mental Disorders, Stellenbosch University, Cape Town, South Africa.
⁷² Research Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.
⁷³ Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Department of Psychology, City, University of London, London, United Kingdom.
⁷⁴ Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California.
⁷⁵ Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois.
⁷⁶ Imaging Genetics and Neuroinformatics Laboratory, Department of Psychology, Georgia State University, Atlanta, Georgia; Mind Research Network, Albuquerque, New Mexico.

PMID: 30470561
PMCID: PMC7041557
DOI: 10.1016/j.biopsych.2018.10.003

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Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.
van Erp TGM, Walton E, Hibar DP, Schmaal L, Jiang W, Glahn DC, Pearlson GD, Yao N, Fukunaga M, Hashimoto R, Okada N, Yamamori H, Bustillo JR, Clark VP, Agartz I, Mueller BA, Cahn W, de Zwarte SMC, Hulshoff Pol HE, Kahn RS, Ophoff RA, van Haren NEM, Andreassen OA, Dale AM, Doan NT, Gurholt TP, Hartberg CB, Haukvik UK, Jørgensen KN, Lagerberg TV, Melle I, Westlye LT, Gruber O, Kraemer B, Richter A, Zilles D, Calhoun VD, Crespo-Facorro B, Roiz-Santiañez R, Tordesillas-Gutiérrez D, Loughland C, Carr VJ, Catts S, Cropley VL, Fullerton JM, Green MJ, Henskens FA, Jablensky A, Lenroot RK, Mowry BJ, Michie PT, Pantelis C, Quidé Y, Schall U, Scott RJ, Cairns MJ, Seal M, Tooney PA, Rasser PE, Cooper G, Shannon Weickert C, Weickert TW, Morris DW, Hong E, Kochunov P, Beard LM, Gur RE, Gur RC, Satterthwaite TD, Wolf DH, Belger A, Brown GG, Ford JM, Macciardi F, Mathalon DH, O'Leary DS, Potkin SG, Preda A, Voyvodic J, Lim KO, McEwen S, Yang F, Tan Y, Tan S, Wang Z, Fan F, Chen J, Xiang H, Tang S, Guo H, Wan P, Wei D, Bockholt HJ, Ehrlich S, Wolthusen RPF, King MD, Shoemaker JM, Sponheim SR, De Haan L, Koenders L, Machielsen MW, van Amelsvoort T, Veltman DJ, Assogna F, Banaj N, de Rossi P, Iorio … See abstract for full author list ➔ van Erp TGM, et al. Biol Psychiatry. 2018 Nov 1;84(9):644-654. doi: 10.1016/j.biopsych.2018.04.023. Epub 2018 May 14. Biol Psychiatry. 2018. PMID: 29960671 Free PMC article.
New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?
Vita A, De Peri L. Vita A, et al. Biol Psychiatry. 2019 Apr 1;85(7):e33. doi: 10.1016/j.biopsych.2018.07.029. Epub 2018 Nov 22. Biol Psychiatry. 2019. PMID: 30470560 No abstract available.

References

1. van Erp TGM, Walton E, Hibar DP, Schmaal L, Jiang W, Glahn DC, et al. (2018): Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics through Meta Analysis (ENIGMA) Consortium. Biol Psychiatry. . doi: 10.1016/j.biopsych.2018.04.023. - DOI - PMC - PubMed
1. van Erp TGM, Hibar DP, Rasmussen JM, Glahn DC, Pearlson GD, Andreassen OA, et al. (2016): Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry. 21: 585. - PMC - PubMed
1. Okada N, Fukunaga M, Yamashita F, Koshiyama D, Yamamori H, Ohi K, et al. (2016): Abnormal asymmetries in subcortical brain volume in schizophrenia. Mol Psychiatry. 21: 1460–1466. - PMC - PubMed
1. Button KS, Ioannidis JPA, Mokrysz C, Nosek BA, Flint J, Robinson ESJ, Munafò MR (2013): Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci. 14: 365–376. - PubMed
1. Ioannidis JPA (2017): Acknowledging and Overcoming Nonreproducibility in Basic and Preclinical Research. JAMA. 317: 1019–1020. - PubMed

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