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Comment
. 2018 Dec 3;215(12):2967-2968.
doi: 10.1084/jem.20182069. Epub 2018 Nov 23.

Deciphering cancer fibroblasts

Giulia Biffi  1 , David A Tuveson  2
Affiliations
Comment

Deciphering cancer fibroblasts

Giulia Biffi et al. J Exp Med. .

Abstract

In this issue of JEM, Raz et al. (https://doi.org/10.1084/jem.20180818) identify a subset of bone marrow-derived cells that uniquely promotes breast cancer angiogenesis and tumor growth. The existence of functional heterogeneity among stromal populations motivates further fundamental and therapeutic inquiries.

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Figures

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Insights from Giulia Biffi and David A. Tuveson.
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Model explaining the functional differences between two stromal populations in the breast tumor microenvironment. Increased presence of PDGFRα-negative BM-derived stromal cells induces angiogenesis and tumor growth, while reducing macrophage infiltration and overall PDGFRα positivity.
See this image and copyright information in PMC

Comment on

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