Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Dec;58(8):3229-3239.
doi: 10.1007/s00394-018-1866-z. Epub 2018 Nov 23.

Association between erythrocyte fatty acids in de novo lipogenesis pathway and DXA-derived body fat and trunk fat distribution in Chinese adults: a prospective study

Fang-Fang Zeng  1   2 , Zhan-Yong Chen  1 , Ju-Sheng Zheng  3 , Jie-Sheng Lin  1 , Yi-Hong Li  1 , Rui Qiu  1 , Cheng Wang  1 , Li-Li Sun  1 , Yu-Ming Chen  4   5
Affiliations

Association between erythrocyte fatty acids in de novo lipogenesis pathway and DXA-derived body fat and trunk fat distribution in Chinese adults: a prospective study

Fang-Fang Zeng et al. Eur J Nutr. 2019 Dec.

Abstract

Purpose: Higher levels of fatty acids (FAs) in the de novo lipogenesis (DNL) pathway might be associated with higher levels of fat mass (FM), while limited evidence is available from the general population. We aimed to examine the associations between DNL-FAs and body fat and fat distribution in a general population of Chinese adults.

Methods: This community-based prospective cohort study included 3,075 participants (68% women) aged 40-75 years in urban Guangzhou, China. We measured erythrocyte DNL-FAs composition (including C16:0, C16:1n-7, C18:0, and C18:1n-9) at baseline and %FM over the total body (TB), trunk, limbs, android (A) and gynoid (G) regions after 3.2 years and 6.3 years of follow-up, respectively.

Results: Generally, higher proportions of individual erythrocyte DNL-FAs and their combined index were positively associated with adipose indices in the multivariable cross-sectional and longitudinal analyses. The cross-sectional percentage mean differences in quartile 4 (vs. 1) of the DNL index were 3.43% (TB), 4.56% (trunk), and 2.67% (A/G ratio) (all P trends < 0.01). The corresponding values in longitudinal changes of adipose indices were 1.40% (TB), 1.78% (trunk), and 1.32% (A) (all P trends < 0.05). The above associations tended to be more pronounced in the trunk and android area than the limbs and gynoid area.

Conclusions: Erythrocyte DNL-FAs may contribute to an increase in total body fat in Chinese adults, particularly FM distributed in trunk and abdominal regions.

Keywords: Body fat; Chinese adults; De novo lipogenesis; Erythrocyte fatty acids; Pathway; Prospective study.

PubMed Disclaimer

References

    1. Bray GA, Fruhbeck G, Ryan DH, Wilding JP (2016) Management of obesity. Lancet 387:1947–1956. https://doi.org/10.1016/S0140-6736(16)00271-3 doi - DOI - PubMed
    1. Mousavi SN, Koohdani F, Shidfar F, Eslaminejad MB (2016) Comparison of maternal isocaloric high carbohydrate and high fat diets on osteogenic and adipogenic genes expression in adolescent mice offspring. Nutr Metab (Lond) 13:69. https://doi.org/10.1186/s12986-016-0130-x - DOI
    1. Saadatian-Elahi M, Slimani N, Chajes V, Jenab M, Goudable J, Biessy C, Ferrari P, Byrnes G, Autier P, Peeters PH, Ocké M, Bueno de Mesquita B, Johansson I, Hallmans G, Manjer J, Wirfält E, González CA, Navarro C, Martinez C, Amiano P, Suárez LR, Ardanaz E, Tjønneland A, Halkjaer J, Overvad K, Jakobsen MU, Berrino F, Pala V, Palli D, Tumino R, Vineis P, Santucci de Magistris M, Spencer EA, Crowe FL, Bingham S, Khaw KT, Linseisen J, Rohrmann S, Boeing H, Noethlings U, Olsen KS, Skeie G, Lund E, Trichopoulou A, Oustoglou E, Clavel-Chapelon F, Riboli E (2009) Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 89:331–346. https://doi.org/10.3945/ajcn.2008.26834 - DOI - PubMed
    1. Fretts AM, Mozaffarian D, Siscovick DS, King IB, McKnight B, Psaty BM, Rimm EB, Sitlani C, Sacks FM, Song X, Sotoodehnia N, Spiegelman D, Lemaitre RN (2016) Associations of plasma phospholipid SFAs with total and cause-specific mortality in older adults differ according to SFA chain length. J Nutr 146:298–305. https://doi.org/10.3945/jn.115.222117 - DOI - PubMed
    1. Hagenfeldt L, Wahren J, Pernow B, Raf L (1972) Uptake of individual free fatty acids by skeletal muscle and liver in man. J Clin Invest 51:2324–2330. https://doi.org/10.1172/JCI107043 - DOI - PubMed - PMC

LinkOut - more resources