Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism

doi:10.1016/j.psychres.2018.11.029

. 2019 Jan:271:111-113.

doi: 10.1016/j.psychres.2018.11.029. Epub 2018 Nov 15.

Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism

Affiliations

¹ Translational Research Group on Mental Health (GPTranSMe), Dom Bosco Catholic University, Campo Grande, Brazil; Institute of Psychiatry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; Departments of Psychiatry, Neuroscience, Genetics and Genomics, Icahn School of Medicine at Mt. Sinai Medical Center, New York, NY, USA. Electronic address: barcielaveras@hotmail.com.
² Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology & Neuroscience and Psychiatry, New York University, New York, NY, USA; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany.
³ Columbia University Mailman School of Public Health, New York, NY, USA.
⁴ Department of Psychiatry, Columbia University, New York, NY USA.
⁵ Institute of Psychiatry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
⁶ National Institute of Mental Health, Bethesda, EUA.
⁷ Translational Research Group on Mental Health (GPTranSMe), Dom Bosco Catholic University, Campo Grande, Brazil.
⁸ University of Dayton, Department of Psychology, Dayton, OH, USA.
⁹ Departments of Psychiatry, Neuroscience, Genetics and Genomics, Icahn School of Medicine at Mt. Sinai Medical Center, New York, NY, USA.

PMID: 30472504
DOI: 10.1016/j.psychres.2018.11.029

Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism

André B Veras et al. Psychiatry Res. 2019 Jan.

. 2019 Jan:271:111-113.

doi: 10.1016/j.psychres.2018.11.029. Epub 2018 Nov 15.

Authors

Affiliations

¹ Translational Research Group on Mental Health (GPTranSMe), Dom Bosco Catholic University, Campo Grande, Brazil; Institute of Psychiatry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; Departments of Psychiatry, Neuroscience, Genetics and Genomics, Icahn School of Medicine at Mt. Sinai Medical Center, New York, NY, USA. Electronic address: barcielaveras@hotmail.com.
² Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology & Neuroscience and Psychiatry, New York University, New York, NY, USA; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany.
³ Columbia University Mailman School of Public Health, New York, NY, USA.
⁴ Department of Psychiatry, Columbia University, New York, NY USA.
⁵ Institute of Psychiatry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
⁶ National Institute of Mental Health, Bethesda, EUA.
⁷ Translational Research Group on Mental Health (GPTranSMe), Dom Bosco Catholic University, Campo Grande, Brazil.
⁸ University of Dayton, Department of Psychology, Dayton, OH, USA.
⁹ Departments of Psychiatry, Neuroscience, Genetics and Genomics, Icahn School of Medicine at Mt. Sinai Medical Center, New York, NY, USA.

PMID: 30472504
DOI: 10.1016/j.psychres.2018.11.029

Abstract

The association of early trauma exposure with current cognition was examined in a research series of 56 schizophrenia cases with respect to the BDNF Val66Met polymorphism (rs6265, Val66Val, Val66Met, Met66Met), as met allele carriers have reduced neurotrophic activity. The Perceptual Organization Index had a significant negative correlation with trauma exposures only in met carriers, including early physical abuse, general trauma after age 18 years, and physical abuse. Within the Val66Val subgroup, there were no significant correlations between WAIS indices and traumatic experiences.

Keywords: BDNF; Schizophrenia; Trauma.

PubMed Disclaimer

Cited by

BDNF gene Val66Met polymorphisms as a predictor for clinical presentation in schizophrenia - recent findings.
Farcas A, Hindmarch C, Iftene F. Farcas A, et al. Front Psychiatry. 2023 Oct 11;14:1234220. doi: 10.3389/fpsyt.2023.1234220. eCollection 2023. Front Psychiatry. 2023. PMID: 37886115 Free PMC article.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

RC1 MH088843/MH/NIMH NIH HHS/United States

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism

Affiliations

Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous