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Review
. 2018 Oct;83(10):1161-1172.
doi: 10.1134/S0006297918100024.

Advances in the Application of Modified Nucleotides in SELEX Technology

O M Antipova  1   2 , E G Zavyalova  3   2 , A V Golovin  2   4   5 , G V Pavlova  2   5   6   7 , A M Kopylov  3   2 , R V Reshetnikov  2   4   5   6
Affiliations
Review

Advances in the Application of Modified Nucleotides in SELEX Technology

O M Antipova et al. Biochemistry (Mosc). 2018 Oct.

Abstract

Aptamers are widely used as molecular recognition elements for detecting and blocking functional biological molecules. Since the common "alphabet" of DNA and RNA consists of only four letters, the chemical diversity of aptamers is less than the diversity of protein recognition elements built of 20 amino acids. Chemical modification of nucleotides enlarges the potential of DNA/RNA aptamers. This review describes the latest achievements in a variety of approaches to aptamers selection with an extended genetic alphabet.

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