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. 2018 Oct;1(2):147-152.
doi: 10.1093/jamiaopen/ooy033. Epub 2018 Aug 21.

Accrual to Clinical Trials (ACT): A Clinical and Translational Science Award Consortium Network

Shyam Visweswaran  1 , Michael J Becich  1 , Vincent S D'Itri  2 , Elaina R Sendro  2 , Douglas MacFadden  3 , Nicholas R Anderson  4 , Karen A Allen  5 , Dipti Ranganathan  6 , Shawn N Murphy  7 , Elaine H Morrato  8 , Harold A Pincus  9 , Robert Toto  10 , Gary S Firestein  11 , Lee M Nadler  3 , Steven E Reis  12
Affiliations

Accrual to Clinical Trials (ACT): A Clinical and Translational Science Award Consortium Network

Shyam Visweswaran et al. JAMIA Open. 2018 Oct.

Abstract

The Accrual to Clinical Trials (ACT) network is a federated network of sites from the National Clinical and Translational Science Award (CTSA) Consortium that has been created to significantly increase participant accrual to multi-site clinical trials. The ACT network represents an unprecedented collaboration among diverse CTSA sites. The network has created governance and regulatory frameworks and a common data model to harmonize electronic health record (EHR) data, and deployed a set of Informatics for Integrating Biology and the Bedside (i2b2) data repositories that are linked by the Shared Health Research Information Network (SHRINE) platform. It provides investigators the ability to query the network in real time and to obtain aggregate counts of patients who meet clinical trial inclusion and exclusion criteria from sites across the United States. The ACT network infrastructure provides a basis for cohort discovery and for developing new informatics tools to identify and recruit participants for multi-site clinical trials.

Keywords: accrual; clinical data research network; clinical trials; cohort discovery; electronic health records.

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Figures

Figure 1.
Figure 1.
The Accrual to Clinical Trials network organization that includes the PI Group, the executive committee, the five work groups, staff at each site, and the central project management team.
Figure 2.
Figure 2.
Locations of sites in the Accrual to Clinical Trials network.
Figure 3.
Figure 3.
An example report from the “smoke test” that provides an overview of connectivity and configuration status of the data repository at each site. A complete report will contain a row of results for each site that is connected to the Accrual to Clinical Trials network.
See this image and copyright information in PMC

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