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Comment
. 2019 Jan;114(1):21-23.
doi: 10.1111/add.14491. Epub 2018 Nov 25.

Response to commentaries: The quest(ion) remains in the search for a meaningful reduction-based end-point

Brian D Kiluk  1 , Garrett M Fitzmaurice  2   3 , Eric C Strain  4 , Roger D Weiss  2   5
Affiliations
Comment

Response to commentaries: The quest(ion) remains in the search for a meaningful reduction-based end-point

Brian D Kiluk et al. Addiction. 2019 Jan.

Abstract

There are multiple challenges toward the identification and acceptance of a meaningful reduction-based endpoint for use in drug use disorder medication efficacy clinical trials. Evaluation of change in diagnostic criteria, and severity metrics based on criterion counts, may be a promising approach for future research.

Keywords: Clinically meaningful outcome; DSM-5; functioning; negative consequences; substance use disorders; treatment end-point.

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References

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