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Review
. 2019 Feb;61(2):145-152.
doi: 10.1007/s12033-018-0136-x.

Oxidative Damages to Eye Stem Cells, in Response to, Bright and Ultraviolet Light, Their Associated Mechanisms, and Salvage Pathways

Bipasha Bose  1 , Abdur Rashid Najwa  2 , Sudheer Shenoy P  3
Affiliations
Review

Oxidative Damages to Eye Stem Cells, in Response to, Bright and Ultraviolet Light, Their Associated Mechanisms, and Salvage Pathways

Bipasha Bose et al. Mol Biotechnol. 2019 Feb.

Abstract

The surface of the eye is continuously exposed to the harshness of the external environment. As a homeostatic mechanism for replenishing the worn off cells of the ocular surface, a balance is maintained via the role of ocular stem cells. However, under extreme conditions of harshness like exposure to bright and ultraviolet light, the ocular stem cells are unable to do the repair mechanisms resulting in severe impairment of vision and disturbances in the eye. This work reappraises the recent understandings of mechanisms of oxidative damages caused to the ocular stem cells by UV/bright light and their probable mitigation.

Keywords: Cell signalling; Ocular stem cells; Oxidative damage; UVA; UVB; UVC.

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References

    1. Science. 2000 Mar 17;287(5460):2032-6 - PubMed
    1. J Biol Chem. 2000 Jul 7;275(27):20444-9 - PubMed
    1. Curr Eye Res. 2001 Mar;22(3):165-73 - PubMed
    1. J Biol Chem. 2002 Jan 4;277(1):366-71 - PubMed
    1. J Histochem Cytochem. 2002 Mar;50(3):341-51 - PubMed

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