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Randomized Controlled Trial
. 2019 Jan;21(1):29-36.
doi: 10.1111/jch.13434. Epub 2018 Nov 26.

Diagnosing hypertension in Indigenous Canadians (DREAM-GLOBAL): A randomized controlled trial to compare the effectiveness of short message service messaging for management of hypertension: Main results

Sheldon W Tobe  1   2 , Karen Yeates  3 , Norm R C Campbell  4 , Marion A Maar  2 , Nancy Perkins  1 , Peter P Liu  5 , Jessica Sleeth  3 , Colin McAllister  6 , Diane Hua-Stewart  1 , George Wells  5 , Jordan Bernick  5
Affiliations
Randomized Controlled Trial

Diagnosing hypertension in Indigenous Canadians (DREAM-GLOBAL): A randomized controlled trial to compare the effectiveness of short message service messaging for management of hypertension: Main results

Sheldon W Tobe et al. J Clin Hypertens (Greenwich). 2019 Jan.

Abstract

Hypertension, the leading cause of cardiovascular morbidity and mortality, affects more than 1 billion people globally. The rise in mobile health in particular the use of mobile phones and short message service (SMS) to support disease management provides an opportunity to improve hypertension awareness, treatment, and control, in remote and vulnerable patient populations. The primary objective of this randomized controlled study was to assess the effect of active (with hypertension specific management SMS) or passive (health behaviors SMS alone) on the difference in blood pressure (BP) reduction between the active and passive SMS groups in hypertensive Canadian First Nations people from six rural and remote communities. Pragmatic features of the study included shifting of BP measures to non-medical health workers. Despite an overall reduction in BP over the study, there was no difference in the BP change between groups from baseline to final for systolic 0.8 (95% CI -4.2 to 5.8 mm Hg) or diastolic -1.0 (95% CI -3.7 to 1.8 mm Hg, P = 0.5) BP. Achieved BP control was 37.5% (25.6%-49.4%, 95% CI) in the active group and 32.8% (20.6%-44.8%, 95% CI) in the passive group (difference in proportions -4.74% (-21.7% to 12.2%, 95% CI, P = 0.6). The study looked at changes in health services delivery, mobile health technologies, and patient engagement to support better management of hypertension in Canadian First Nations communities. The active hypertension specific SMS did not lead to improvements in BP control.

Trial registration: ClinicalTrials.gov NCT02111226.

Keywords: chronic disease; disease management; health services; hypertension; indigenous; telemedicine; text messaging.

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Conflict of interest statement

NRCC is a paid consultant to the Novartis Foundation to support their program to improve hypertension control in low‐ to middle‐income countries which includes travel support for site visits and a contract to develop a survey (2016‐2017). NRCC has provided paid consultative advice on accurate BP assessment to Midway Corporation (2016) and is an unpaid member of World Action on Salt and Health (WASH).

Figures

Figure 1
Figure 1
CONSORT Flow Diagram—DREAM‐GLOBAL Study (Canada)
Figure 2
Figure 2
PRECIS‐2 Wheel
See this image and copyright information in PMC

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