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. 2020 Aug;34(16):2394-2397.
doi: 10.1080/14786419.2018.1538216. Epub 2018 Nov 26.

In vitro evaluation of Cuscuta reflexa Roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities

Abul Kalam Azad  1 , Farhina Rahman Laboni  2 , Harun Rashid  2 , Sahena Ferdous  3 , Shah Samiur Rashid  4 , Nurkhalida Kamal  5 , Zubair Khalid Labu  2 , M S Islam  6 , Zaidul Islam Sarker  1
Affiliations

In vitro evaluation of Cuscuta reflexa Roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities

Abul Kalam Azad et al. Nat Prod Res. 2020 Aug.

Abstract

The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83 μg/mL while the standard ascorbic acid was 2.48 µg/mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p > 0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50 mg of GAE/g).

Keywords: Cuscuta reflexa; anti-microbial activity; antioxidant; membrane stabilizing; thrombolytic.

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