Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline Among Community Dwelling 55 to 77 Year Olds

Megan Heffernan¹, Gavin Andrews², Maria A Fiatarone Singh^{3

4

5}, Michael Valenzuela^{3

6}, Kaarin J Anstey⁷, Anthony J Maeder⁸, John McNeil⁹, Louisa Jorm¹⁰, Nicola T Lautenschlager^{11

12}, Perminder S Sachdev¹, Jeewani A Ginige¹³, Megan J Hobbs², Christos Boulamatsis¹³, Tiffany Chau¹, Lynne Cobiac¹⁴, Kay L Cox¹⁵, Kenneth Daniel⁴, Victoria M Flood^{16

17}, Yareni Guerrero⁴, Jane Gunn¹⁸, Nidhi Jain⁴, Nicole A Kochan¹, Amit Lampit^{6

11}, Yorgi Mavros⁴, Jacinda Meiklejohn⁴, Yian Noble⁴, Fiona O'Leary¹⁹, Sue Radd-Vagenas⁴, Courtney C Walton^{6

20}; Maintain Your Brain Collaborative Team; Henry Brodaty¹

Affiliations

¹ Centre for Healthy Brain Ageing, University of New South Wales, Australia.
² Clinical Research Unit for Anxiety and Depression, School of Psychiatry, University of New South Wales, Australia.
³ Sydney Medical School, University of Sydney, Australia.
⁴ Physical Activity, Lifestyle, Ageing and Wellbeing Faculty Research Group, Faculty of Health Sciences, University of Sydney, Australia.
⁵ Hebrew SeniorLife and Jean Meyer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA USA.
⁶ Brain and Mind Centre, University of Sydney, Australia.
⁷ School of Psychology, University of New South Wales, Australia.
⁸ College of Nursing & Health Sciences, Flinders University, Australia.
⁹ Monash University, Australia.
¹⁰ Centre for Big Data Research in Health, University of New South Wales, Australia.
¹¹ University of Melbourne, Australia.
¹² North Western Mental Health, Melbourne Health, Melbourne, Australia.
¹³ Western Sydney University, Australia.
¹⁴ CSIRO Health and Biosecurity.
¹⁵ Medical School, University of Western Australia, Perth, Australia.
¹⁶ Faculty of Health Sciences, University of Sydney, Australia.
¹⁷ Western Sydney Local Health District, Westmead Hospital, Australia.
¹⁸ Department of General Practice, University of Melbourne, Melbourne, Australia.
¹⁹ Nutrition and Dietetics Group, School of Life and Environmental Science, Faculty of Science & The Charles Perkins Centre, University of Sydney, Australia.
²⁰ School of Psychology, University of Queensland, Melbourne, Australia.

PMID: 30475762
PMCID: PMC6700632
DOI: 10.3233/JAD-180572

Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline Among Community Dwelling 55 to 77 Year Olds

Megan Heffernan et al. J Alzheimers Dis. 2019.

. 2019;70(s1):S221-S237.

doi: 10.3233/JAD-180572.

Authors

Affiliations

¹ Centre for Healthy Brain Ageing, University of New South Wales, Australia.
² Clinical Research Unit for Anxiety and Depression, School of Psychiatry, University of New South Wales, Australia.
³ Sydney Medical School, University of Sydney, Australia.
⁴ Physical Activity, Lifestyle, Ageing and Wellbeing Faculty Research Group, Faculty of Health Sciences, University of Sydney, Australia.
⁵ Hebrew SeniorLife and Jean Meyer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA USA.
⁶ Brain and Mind Centre, University of Sydney, Australia.
⁷ School of Psychology, University of New South Wales, Australia.
⁸ College of Nursing & Health Sciences, Flinders University, Australia.
⁹ Monash University, Australia.
¹⁰ Centre for Big Data Research in Health, University of New South Wales, Australia.
¹¹ University of Melbourne, Australia.
¹² North Western Mental Health, Melbourne Health, Melbourne, Australia.
¹³ Western Sydney University, Australia.
¹⁴ CSIRO Health and Biosecurity.
¹⁵ Medical School, University of Western Australia, Perth, Australia.
¹⁶ Faculty of Health Sciences, University of Sydney, Australia.
¹⁷ Western Sydney Local Health District, Westmead Hospital, Australia.
¹⁸ Department of General Practice, University of Melbourne, Melbourne, Australia.
¹⁹ Nutrition and Dietetics Group, School of Life and Environmental Science, Faculty of Science & The Charles Perkins Centre, University of Sydney, Australia.
²⁰ School of Psychology, University of Queensland, Melbourne, Australia.

PMID: 30475762
PMCID: PMC6700632
DOI: 10.3233/JAD-180572

Abstract

Background: Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort.

Methods: MYB aims to recruit 8,500 non-demented community dwelling 55 to 77 year olds from the Sax Institute's 45 and Up Study in New South Wales, Australia. Participants will be screened for risk factors related to four modules that comprise the MYB intervention: physical activity, nutrition, mental health, and cognitive training. Targeting risk factors will enable interventions to be personalized so that participants receive the most appropriate modules. MYB will run for three years and up to four modules will be delivered sequentially each quarter during year one. Upon completing a module, participants will continue to receive less frequent booster activities for their eligible modules (except for the mental health module) until the end of the trial.

Discussion: MYB will be the largest internet-based trial to attempt to prevent cognitive decline and potentially dementia. If successful, MYB will provide a model for not just effective intervention among older adults, but an intervention that is scalable for broad use.

Keywords: Alzheimer’s disease; clinical trial; cognitive decline; cognitive training; dementia; depression; non-pharmacological; nutrition; physical activity; randomized controlled trial.

PubMed Disclaimer

Conflict of interest statement

Authors’ disclosures available online (https://www.j-alz.com/manuscript-disclosures/18-0572r1).

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References

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Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline Among Community Dwelling 55 to 77 Year Olds

Affiliations

Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline Among Community Dwelling 55 to 77 Year Olds

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Associated data

LinkOut - more resources

Full Text Sources

Medical