Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Aug 25;16(16):8011-28.
doi: 10.1093/nar/16.16.8011.

The organization and transcription of the galactose gene cluster of Kluyveromyces lactis

T D Webster  1 , R C Dickson
Affiliations
Free PMC article

The organization and transcription of the galactose gene cluster of Kluyveromyces lactis

T D Webster et al. Nucleic Acids Res. .
Free PMC article

Abstract

The yeast Kluyveromyces lactis grows on galactose by inducing the Leloir pathway enzymes-kinase, epimerase, and transferase. To investigate the molecular mechanism for regulating expression of this metabolic pathway we isolated GAL1, GAL7, GAL10, which code for kinase, transferase, and epimerase, respectively, and characterized their size, organization, and transcriptional regulation. Our results indicate that induction of the Leloir pathway in K. lactis occurs at the level of transcription and that the organization and regulation of the GAL gene cluster in K. lactis is closely related to the homologous gene cluster in Saccharomyces cerevisiae. Likewise, the Upstream Activator Sequences that regulate induction of the GAL genes are similar in base sequence, number and relative location in the two yeasts.

PubMed Disclaimer

References

    1. Mol Cell Biol. 1987 Mar;7(3):1111-21 - PubMed
    1. Mol Cell Biol. 1987 Feb;7(2):780-6 - PubMed
    1. Mol Cell Biol. 1981 Jul;1(7):629-34 - PubMed
    1. Nucleic Acids Res. 1988 Aug 25;16(16):8192-4 - PubMed
    1. Mol Cell Biol. 1987 Dec;7(12):4369-76 - PubMed

Publication types