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Review
. 2018 Nov 23;19(12):3729.
doi: 10.3390/ijms19123729.

Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment

Jon G Steller  1 , Jeffrey R Alberts  2 , April E Ronca  3   4
Affiliations
Review

Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment

Jon G Steller et al. Int J Mol Sci. .

Abstract

Oxidative stress has been implicated in the pathophysiology of numerous terrestrial disease processes and associated with morbidity following spaceflight. Furthermore, oxidative stress has long been considered a causative agent in adverse reproductive outcomes. The purpose of this review is to summarize the pathogenesis of oxidative stress caused by cosmic radiation and microgravity, review the relationship between oxidative stress and reproductive outcomes in females, and explore what role spaceflight-induced oxidative damage may have on female reproductive and developmental outcomes.

Keywords: cosmic radiation; female; hind-limb unloading; microgravity; oxidative stress; pregnancy; reproduction; spaceflight.

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Conflict of interest statement

The authors declare no conflict of interest.

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