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Editorial
. 2019 Jun;33(3):373-376.
doi: 10.1007/s10877-018-0225-1. Epub 2018 Nov 26.

Phenylephrine-induced recruitable preload from the venous side

Rita Jacobs  1 , Stijn Lochy  1   2 , Manu L N G Malbrain  3   4
Affiliations
Editorial

Phenylephrine-induced recruitable preload from the venous side

Rita Jacobs et al. J Clin Monit Comput. 2019 Jun.
No abstract available

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Conflict of interest statement

MLNGM is Professor of Medicine at the Vrije Universiteit Brussel (VUB) and ICU Director at the University Hospital in Brussels (UZB), Belgium. He is founding President of WSACS (The Abdominal Compartment Society, http://www.wsacs.org) and current Treasurer, he is also member of the Medical Advisory Board of Getinge (formerly Pulsion Medical Systems) and Serenno Medical, and consults for ConvaTec, Acelity, Spiegelberg, and Holtech Medical. He is co-founder of the International Fluid Academy (IFA). The IFA is integrated within the not-for-profit charitable organization iMERiT, International Medical Education and Research Initiative, under Belgian law. The IFA website (http://www.fluidacademy.org) is now an official SMACC affiliated site (Social Media and Critical Care) and its content is based on the philosophy of FOAM (Free Open Access Medical education—#FOAMed). The site recently received the HONcode quality label for medical education (https://www.healthonnet.org/HONcode/Conduct.html?HONConduct519739). The other authors have no potential conflicts of interest in relation to the contents of this paper.

Figures

Fig. 1
Fig. 1
Effect of fluid loading and venoconstriction on volume. a Effect of volume loading on mean systemic filling pressure (Pmsf) and (un)stressed volume. Administration of a fluid bolus increases Pmsf (from Pmsf1 to Pmsf2, indicated respectively by position A (red dot) to B (green dot) on the pressure/volume curve). Unstressed volume remains constant while stressed volume increases. Total volume = unstressed + stressed increases, carrying a risk for fluid overload. See text for explanation. b Effect of venoconstriction and venodilation on mean systemic filling pressure (Pmsf) and (un)stressed volume. Venoconstriction increases Pmsf (from Pmsf1 to Pmsf2, indicated respectively by position A (red dot) to B (green dot) on the pressure/volume curve). Unstressed volume decreases while stressed volume increases. Total volume = unstressed + stressed remains constant, resulting in an auto-transfusion effect. Venodilation as seen in sepsis (vasoplegia) decreases Pmsf (from Pmsf1 to Pmsf3, indicated respectively by position A (red dot) to C (blue dot) on the pressure/volume curve). Unstressed volume increases while stressed volume decreases. Total volume = unstressed + stressed remains constant, resulting in an intravascular underfilling effect. See text for explanation
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