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. 1977 Dec;30(3):465-8.

Effect of levamisole on autologous rosette-forming cells in nude mice

J Van Wauwe, G Van Nijen

Effect of levamisole on autologous rosette-forming cells in nude mice

J Van Wauwe et al. Clin Exp Immunol. 1977 Dec.

Abstract

Levamisole depresses the number of autologous rosette-forming cells (ARFC) in the spleen of nude (congenitally athymic) mice. Intravenous administration of 2.5 mg/kg of levamisole produces maximal depression. This effect appears 15 h after injection and is transient, partially disappearing after 48 hr. Dexamisole is devoid of this depressing activity. Thymopoietin, a thymic hormone, is also shown to lower the level of autologous rosette formation. These results suggest a stereospecific interference of levamisole with the maturation of immature T-cell precursors in a manner resembling the action of thymic hormones.

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References

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    1. J Reticuloendothel Soc. 1977 Mar;21(3):175-221 - PubMed
    1. Cell Immunol. 1977 Feb;28(2):274-83 - PubMed
    1. Prog Drug Res. 1976;20:347-83 - PubMed
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