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. 2018 Jun;23(2):e12135.
doi: 10.1111/jabr.12135. Epub 2018 Jun 27.

Phenotypic Features of Central Sensitization

David A Williams  1
Affiliations

Phenotypic Features of Central Sensitization

David A Williams. J Appl Biobehav Res. 2018 Jun.

Abstract

Purpose: The current manuscript reviews approaches for phenotyping central sensitization (CS).

Methods: The manuscript covers the concept of diagnostic phenotyping, use of endophenotypes, biomarkers, and symptom clusters. Specifically, the components of CS that include general sensory sensitivity (assessed by quantitative sensory testing) and a symptom cluster denoting sleep difficulties, pain, affect, cognitive difficulties, and low energy (S.P.A.C.E.).

Results: Each of the assessment domains are described with reference to CS and their presence in chronic overlapping pain conditions (COPCs) - conditions likely influenced by CS.

Conclusions: COPCs likely represent clinical diagnostic phenotypes of CS. Components of CS can also be assessed using QST or self-report instruments designed to assess single elements of CS or more general composite indices.

Keywords: Central Sensitization; Chronic Overlapping Pain Conditions (COPCs); Mental Load; Phenotyping; Sensory Hypersensitivity; Unwellness.

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Conflict of interest statement

CONFLICT OF INTEREST Dr. Williams serves as a consultant to Community Health Focus Inc. He is currently the Immediate Past President of the American Pain Society. There is no conflict associated with the content or preparation of this manuscript.

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