Big bottlenecks in cardiovascular tissue engineering

Ngan F Huang^{1

2

3}, Vahid Serpooshan^{4

5

6}, Viola B Morris^{5

7}, Nazish Sayed⁴, Gaspard Pardon^{4

8}, Oscar J Abilez^{4

9}, Karina H Nakayama^{4

10

11}, Beth L Pruitt^{4

8

12

13}, Sean M Wu^{4

9

14}, Young-Sup Yoon^{5

7}, Jianyi Zhang¹⁵, Joseph C Wu^{4

9

14}

Affiliations

¹ Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, USA. ngantina@stanford.edu.
² Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, 94305, CA, USA. ngantina@stanford.edu.
³ Veteran Affairs Palo Alto Health Care System, Palo Alto, 94304, CA, USA. ngantina@stanford.edu.
⁴ Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, USA.
⁵ Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, 30332, GA, USA.
⁶ Department of Pediatrics, Emory University School of Medicine, Atlanta, 30307, GA, USA.
⁷ Department of Medicine, Division of Cardiology, Emory University, Atlanta, 30307, GA, USA.
⁸ Department of Bioengineering, Stanford University, Stanford, 94305, CA, USA.
⁹ Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, 94305, CA, USA.
¹⁰ Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, 94305, CA, USA.
¹¹ Veteran Affairs Palo Alto Health Care System, Palo Alto, 94304, CA, USA.
¹² Department of Mechanical Engineering, Stanford University, Stanford, 94305, CA, USA.
¹³ Departments of Mechanical Engineering; BioMolecular Science and Engineering; and Molecular, Cellular and Developmental Biology, University of California at Santa Barbara, Santa Barbara, 93106, CA, USA.
¹⁴ Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, 94305, CA, USA.
¹⁵ Department of Bioengineering, School of Medicine, University of Alabama at Birmingham, Birmingham, 35294, AL, USA.

PMID: 30480100
PMCID: PMC6249300
DOI: 10.1038/s42003-018-0202-8

Big bottlenecks in cardiovascular tissue engineering

Ngan F Huang et al. Commun Biol. 2018.

. 2018 Nov 21:1:199.

doi: 10.1038/s42003-018-0202-8. eCollection 2018.

Authors

Affiliations

¹ Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, USA. ngantina@stanford.edu.
² Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, 94305, CA, USA. ngantina@stanford.edu.
³ Veteran Affairs Palo Alto Health Care System, Palo Alto, 94304, CA, USA. ngantina@stanford.edu.
⁴ Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305, CA, USA.
⁵ Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, 30332, GA, USA.
⁶ Department of Pediatrics, Emory University School of Medicine, Atlanta, 30307, GA, USA.
⁷ Department of Medicine, Division of Cardiology, Emory University, Atlanta, 30307, GA, USA.
⁸ Department of Bioengineering, Stanford University, Stanford, 94305, CA, USA.
⁹ Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, 94305, CA, USA.
¹⁰ Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, 94305, CA, USA.
¹¹ Veteran Affairs Palo Alto Health Care System, Palo Alto, 94304, CA, USA.
¹² Department of Mechanical Engineering, Stanford University, Stanford, 94305, CA, USA.
¹³ Departments of Mechanical Engineering; BioMolecular Science and Engineering; and Molecular, Cellular and Developmental Biology, University of California at Santa Barbara, Santa Barbara, 93106, CA, USA.
¹⁴ Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, 94305, CA, USA.
¹⁵ Department of Bioengineering, School of Medicine, University of Alabama at Birmingham, Birmingham, 35294, AL, USA.

PMID: 30480100
PMCID: PMC6249300
DOI: 10.1038/s42003-018-0202-8

Abstract

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

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Conflict of interest statement

J.C.W. has financial interest in Khoris Biosciences. All the remaining authors declare no competing interests.

Figures

**Fig. 1**
Bottlenecks in cardiovascular tissue engineering. These challenges include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional engineered tissues

See this image and copyright information in PMC

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Big bottlenecks in cardiovascular tissue engineering

Affiliations

Big bottlenecks in cardiovascular tissue engineering

Authors

Affiliations

Abstract

Conflict of interest statement

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