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Book

Cryptogenic Cirrhosis

Nicolas Patel  1 , Bashar Sharma  2 , Hrishikesh Samant  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Cryptogenic Cirrhosis

Nicolas Patel et al.
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Excerpt

Cryptogenic cirrhosis is cirrhosis of uncertain etiology that lacks definitive clinical and histological criteria for a specific disease. Cryptogenic cirrhosis accounts for nearly 5% to 30% of cases of cirrhosis and nearly 10% of liver transplants. Although the exact cause of cryptogenic cirrhosis is unknown, there are correlations that non-alcoholic steatohepatitis (NASH) plays a dominant role.

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Conflict of interest statement

Disclosure: Nicolas Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Bashar Sharma declares no relevant financial relationships with ineligible companies.

Disclosure: Hrishikesh Samant declares no relevant financial relationships with ineligible companies.

References

    1. Caldwell S. Cryptogenic cirrhosis: what are we missing? Curr Gastroenterol Rep. 2010 Feb;12(1):40-8. - PubMed
    1. Clark JM, Diehl AM. Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA. 2003 Jun 11;289(22):3000-4. - PubMed
    1. Caldwell SH, Crespo DM. The spectrum expanded: cryptogenic cirrhosis and the natural history of non-alcoholic fatty liver disease. J Hepatol. 2004 Apr;40(4):578-84. - PubMed
    1. Caldwell SH, Lee VD, Kleiner DE, Al-Osaimi AM, Argo CK, Northup PG, Berg CL. NASH and cryptogenic cirrhosis: a histological analysis. Ann Hepatol. 2009 Oct-Dec;8(4):346-52. - PMC - PubMed
    1. Cotrim HP, Paraná R, Braga E, Lyra L. Nonalcoholic steatohepatitis and hepatocellular carcinoma: natural history? Am J Gastroenterol. 2000 Oct;95(10):3018-9. - PubMed

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