Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Nov 27;16(11):e3000062.
doi: 10.1371/journal.pbio.3000062. eCollection 2018 Nov.

Long-distance communication: Looping of human papillomavirus genomes regulates expression of viral oncogenes

Adityarup Chakravorty  1 , Bill Sugden  1
Affiliations
Comment

Long-distance communication: Looping of human papillomavirus genomes regulates expression of viral oncogenes

Adityarup Chakravorty et al. PLoS Biol. .

Abstract

High-risk human papillomaviruses (HPVs) are a major cause of cancers. HPVs infect epithelial cells, and viral oncogenes disrupt several cellular processes, including cell division, differentiation, and apoptosis. Expression of these oncogenes is relatively low in undifferentiated epithelial cells but increases in differentiating cells by unknown mechanisms. In a new study, Parish and colleagues unveil how two cellular proteins, CCCTC-binding factor (CTCF) and Yin Yang 1 (YY1), mediate looping of the HPV18 genome, which regulates expression of viral oncogenes in both dividing and differentiating epithelial cells.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. A graphical representation of the HPV18 genome.
The E6 and E7 oncogenes are shown in red. The other early genes are shown in green, and the late genes are shown in blue. The LCR, which contains multiple YY1-binding sites, is shown in yellow. The CTCF-binding site in the E2 ORF is also noted (in black). CTCF, CCCTC-binding factor; HPV, human papillomavirus; LCR, long control region; YY1, Yin Yang 1.
See this image and copyright information in PMC

Comment on

References

    1. Plummer M, de Martel C, Vignat J, Ferlay J, Bray F, Franceschi S. Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob Heal. 2016; 4(9): e609–16. - PubMed
    1. Tommasino M. The human papillomavirus family and its role in carcinogenesis. Seminars in Cancer Biology. 2014; 26:13–21. 10.1016/j.semcancer.2013.11.002 - DOI - PubMed
    1. Moody CA. Mechanisms by which HPV induces a replication competent environment in differentiating keratinocytes. Viruses. 2017; 10.3390/v9090261 - DOI - PMC - PubMed
    1. Butz K, Ristriani T, Hengstermann A, Denk C, Scheffner M, Hoppe-Seyler F. siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells. Oncogene. 2003; 22(38): 5938–45. 10.1038/sj.onc.1206894 - DOI - PubMed
    1. Jiang M, Milner J. Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene. 2002; 21(39): 6041–8. 10.1038/sj.onc.1205878 - DOI - PubMed

Publication types

Substances