Targeting optimal time for hyperbaric oxygen therapy following carbon monoxide poisoning for prevention of delayed neuropsychiatric sequelae: A retrospective study
- PMID: 30481656
- DOI: 10.1016/j.jns.2018.11.025
Targeting optimal time for hyperbaric oxygen therapy following carbon monoxide poisoning for prevention of delayed neuropsychiatric sequelae: A retrospective study
Abstract
Objectives: Delayed neuropsychiatric sequelae (DNS) are serious complications of carbon monoxide poisoning; neuropsychiatric disorders can occur within a few days of recovery from acute poisoning. Hyperbaric oxygen therapy (HBOT) has been the main treatment of carbon monoxide (CO) poisoning and was recommended as the treatment choice for CO poisoning by the American Undersea and Hyperbaric Medical Society and the Tenth European Consensus Conference on Hyperbaric Medicine of the European Underwater and Baromedical Society. However, the optimal timing for commencing HBOT in patients with CO poisoning remains unknown. We therefore conducted a retrospective study in an attempt to target the optimal time of HBOT for DNS prevention.
Methods: A retrospective review of patient files/medical records was conducted on all patients with CO poisoning admitted to the Emergency Department of Linkou Chang-Gung Memorial Hospital, Taiwan between January 1, 2009 and December 31, 2015. A total of 279 patients who received HBOT were eligible for further DNS detection. DNS was defined as the presence of one of the following neurological, cognitive, or psychological sequelae that were documented in the medical record during hospital stay or outpatient clinic follow-up for at least 6 months. A multivariable logistic regression analysis was employed to identify potential determinants of DNS after receiving HBOT for CO poisoning. A receiver operating characteristic (ROC) curve was used to analyse the influence of duration from CO exposure to HBOT on DNS development.
Results: A Glasgow coma score of <9 (odds ratio [OR], 3.20; 95% confidence interval [CI], 1.19-8.60) and a longer duration from CO exposure to HBOT (OR, 1.06; 95% CI, 1.03-1.09) were associated with a higher risk of DNS. By contrast, the presence of multiple victims from the same incident was associated with a lower risk of DNS. The ROC curve for the duration between CO exposure and HBOT in predicting DNS development demonstrated an area under the curve of 0.638 (95% CI, 0.575-0.698). The optimal cut-off point according to the Youden index was 22.5 h, with a sensitivity of 41.7% and a specificity of 85.9%. We also stratified the duration from CO exposure to HBOT into 5 intervals (< 6 h, 6-11 h, 12-23 h, 24-47 h and ≥ 48 h) and revealed a trend of increasing DNS risk with time.
Conclusions: We identified several potential predictors of DNS in patients with CO poisoning who received HBOT. Multivariable logistic regressions further revealed that longer duration from CO exposure to HBOT, loss of consciousness, and the presence of multiple victims were independent predictors of DNS development. HBOT should be performed as early as possible and preferably within 22.5 h after CO poisoning.
Keywords: Carbon monoxide poisoning; Delayed neuropsychiatric sequelae prevention (DNS); Hyperbaric oxygen therapy (HBOT); Oxidative and antioxidative status; Targeting optimal time for HBOT.
Copyright © 2018 Elsevier B.V. All rights reserved.
Similar articles
-
Real-world effectiveness of hyperbaric oxygen therapy for delayed neuropsychiatric sequelae after carbon monoxide poisoning.Sci Rep. 2021 Sep 28;11(1):19212. doi: 10.1038/s41598-021-98539-y. Sci Rep. 2021. PMID: 34584153 Free PMC article.
-
Predictive Role of QTc Prolongation in Carbon Monoxide Poisoning-Related Delayed Neuropsychiatric Sequelae.Biomed Res Int. 2018 Sep 25;2018:2543018. doi: 10.1155/2018/2543018. eCollection 2018. Biomed Res Int. 2018. PMID: 30356348 Free PMC article. Clinical Trial.
-
Initial creatine kinase level as predictor for delayed neuropsychiatric sequelae associated with acute carbon monoxide poisoning.Am J Emerg Med. 2021 May;43:195-199. doi: 10.1016/j.ajem.2020.02.054. Epub 2020 Feb 25. Am J Emerg Med. 2021. PMID: 32165069
-
Hyperbaric oxygen for the treatment of carbon monoxide-induced delayed neurological sequelae: a case report and review of the literature.Diving Hyperb Med. 2024 Mar 31;54(1):65-68. doi: 10.28920/dhm54.1.65-68. Diving Hyperb Med. 2024. PMID: 38507912 Free PMC article. Review.
-
Utilizing Cerebral Perfusion Scan and Diffusion-tensor MR Imaging to Evaluate the Effect of Hyperbaric Oxygen Therapy in Carbon Monoxide-induced Delayed Neuropsychiatric Seqeulae- A Case Report and Literature Review.Acta Neurol Taiwan. 2015 Jun;24(2):57-62. Acta Neurol Taiwan. 2015. PMID: 26179838 Review.
Cited by
-
Association between Glasgow Coma Scale in Early Carbon Monoxide Poisoning and Development of Delayed Neurological Sequelae: A Meta-Analysis.J Pers Med. 2022 Apr 14;12(4):635. doi: 10.3390/jpm12040635. J Pers Med. 2022. PMID: 35455751 Free PMC article. Review.
-
Management of delayed encephalopathy after CO poisoning: An evidence-based narrative review.Medicine (Baltimore). 2019 Dec;98(49):e18199. doi: 10.1097/MD.0000000000018199. Medicine (Baltimore). 2019. PMID: 31804341 Free PMC article.
-
Effect of Hyperbaric Oxygen on Neurologic Sequelae and All-Cause Mortality in Patients with Carbon Monoxide Poisoning: A Meta-Analysis of Randomized Controlled Trials.Med Sci Monit. 2019 Oct 13;25:7684-7693. doi: 10.12659/MSM.917065. Med Sci Monit. 2019. PMID: 31606731 Free PMC article.
-
Analysis of prognosis of neurological sequelae in children with carbon monoxide poisoning.Sci Rep. 2024 Dec 2;14(1):29972. doi: 10.1038/s41598-024-81634-1. Sci Rep. 2024. PMID: 39623004 Free PMC article.
-
Early and late adverse clinical outcomes of severe carbon monoxide intoxication: A cross-sectional retrospective study.PLoS One. 2024 Aug 30;19(8):e0301399. doi: 10.1371/journal.pone.0301399. eCollection 2024. PLoS One. 2024. PMID: 39213322 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical