[Advances in combination therapy of ombitasvir and dasabuvir for chronic hepatitis C virus genotype 1 infection]
- PMID: 30481875
- DOI: 10.3760/cma.j.issn.1007-3418.2018.09.018
[Advances in combination therapy of ombitasvir and dasabuvir for chronic hepatitis C virus genotype 1 infection]
Abstract
Since 2014, the United States and Europe has approved all oral, interferon free- regimens that combine with direct-acting antiviral agents. Hence, the sustained virological response rate of patients with chronic HCV genotype 1 infection has improved over 90%, and the treatment modalities has introduced a new era. These drugs, ombitasvir and dasabuvir, received customary authorization of Food and Drug Administration in 2015 and are the first combined direct-acting antiviral agents for treating HCV genotype 1 infection. It has superior application prospects in China because of its high-sustained virological response rate and safety profile. This article reviews the pharmacokinetics, drug interactions, efficacy and safety of this therapeutic regimen.
自2014年全口服不含干扰素的直接抗病毒方案在美国、欧洲陆续获批准，基因1型丙型肝炎病毒感染患者的持续病毒学应答率提高到90%以上，慢性丙型肝炎基因1型的治疗进入了一个新的时代。作为第一个全新的直接抗病毒药物组合，奥比帕利联合达塞布韦于2015年经食品和药品管理局批准治疗基因1型慢性丙型肝炎患者，其持续病毒学应答率高、安全性好，在我国具有较好的应用前景。现对该治疗方案的药代动力学、药物相互作用、疗效及安全性等方面进行综述。.
Keywords: Direct-acting antiviral agents; Hepatitis C virus; Therapy.
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