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. 2018 Nov 27;19(1):455.
doi: 10.1186/s12859-018-2493-7.

dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions

Quanya Liu  1 , Peng Chen  2 , Bing Wang  3 , Jun Zhang  4 , Jinyan Li  5
Affiliations

dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions

Quanya Liu et al. BMC Bioinformatics. .

Abstract

Background: Protein-protein interactions (PPIs) play important roles in biological functions. Studies of the effects of mutants on protein interactions can provide further understanding of PPIs. Currently, many databases collect experimental mutants to assess protein interactions, but most of these databases are old and have not been updated for several years.

Results: To address this issue, we manually curated a kinetic and thermodynamic database of mutant protein interactions (dbMPIKT) that is freely accessible at our website. This database contains 5291 mutants in protein interactions collected from previous databases and the literature published within the last three years. Furthermore, some data analysis, such as mutation number, mutation type, protein pair source and network map construction, can be performed online.

Conclusion: Our work can promote the study on PPIs, and novel information can be mined from the new database. Our database is available in http://DeepLearner.ahu.edu.cn/web/dbMPIKT/ for use by all, including both academics and non-academics.

Keywords: Kinetic data; Mutants; Protein-protein interactions; Thermodynamic data.

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Conflict of interest statement

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Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
The flowchart of data collection
Fig. 2
Fig. 2
The database structure of dbMPIKT
Fig. 3
Fig. 3
The data distribution of the four data sets
Fig. 4
Fig. 4
Part of interactions on the network map. Each node in the picture represents a protein, and the connection between nodes represents an interaction
See this image and copyright information in PMC

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