. 2018 Nov;23(47):1800617.

doi: 10.2807/1560-7917.ES.2018.23.47.1800617.

Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018

Daniel Golparian¹, Lisa Rose², Almida Lynam³, Aia Mohamed², Beatrice Bercot⁴, Makoto Ohnishi⁵, Brendan Crowley^{2

6

7}, Magnus Unemo^{1

7}

Affiliations

¹ WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Swedish Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
² Department of Clinical Microbiology, University of Dublin, Trinity College, St. James's Hospital, Dublin, Ireland.
³ Guide Clinic, St. James's Hospital, Dublin, Ireland.
⁴ APHP, St Louis Hospital, Laboratory of Microbiology; French National Reference Center for Bacterial STI, Associated laboratory for gonococci; Paris Diderot University, IAME, Sorbonne Paris Cité, Paris, France.
⁵ Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
⁶ National Gonococcal Reference Laboratory, St. James's Hospital, Dublin, Ireland.
⁷ Authors contributed equally to the work and share joint authorship.

PMID: 30482267
PMCID: PMC6341943
DOI: 10.2807/1560-7917.ES.2018.23.47.1800617

Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018

Daniel Golparian et al. Euro Surveill. 2018 Nov.

. 2018 Nov;23(47):1800617.

doi: 10.2807/1560-7917.ES.2018.23.47.1800617.

Authors

Daniel Golparian¹, Lisa Rose², Almida Lynam³, Aia Mohamed², Beatrice Bercot⁴, Makoto Ohnishi⁵, Brendan Crowley^{2

6

7}, Magnus Unemo^{1

7}

Affiliations

¹ WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Swedish Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
² Department of Clinical Microbiology, University of Dublin, Trinity College, St. James's Hospital, Dublin, Ireland.
³ Guide Clinic, St. James's Hospital, Dublin, Ireland.
⁴ APHP, St Louis Hospital, Laboratory of Microbiology; French National Reference Center for Bacterial STI, Associated laboratory for gonococci; Paris Diderot University, IAME, Sorbonne Paris Cité, Paris, France.
⁵ Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
⁶ National Gonococcal Reference Laboratory, St. James's Hospital, Dublin, Ireland.
⁷ Authors contributed equally to the work and share joint authorship.

PMID: 30482267
PMCID: PMC6341943
DOI: 10.2807/1560-7917.ES.2018.23.47.1800617

Abstract

We describe a multidrug-resistant Neisseria gonorrhoeae urethritis case with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Ireland, August 2018. Whole-genome sequencing showed that the isolate IR72 belongs to the internationally spreading multidrug-resistant ceftriaxone-resistant FC428 clade, initially described in Japan in 2015. IR72 was assigned MSLT ST1903, NG-MAST ST17842 and NG-STAR type 1133, including the ceftriaxone resistance-mediating penA-60.001. Global awareness of spreading ceftriaxone-resistant gonococcal strains that threaten recommended dual therapies is essential.

Keywords: FC428; Ireland; Neisseria gonorrhoeae; azithromycin; ceftriaxone; gonorrhoea; multidrug-resistant; resistance; treatment.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

**Figure**
Phylogenetic tree including the whole genome sequence of the ceftriaxone-resistant isolate (IR72), Ireland, August 2018

See this image and copyright information in PMC

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Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018

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Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018

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