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. 2018 Nov;23(47):1800617.
doi: 10.2807/1560-7917.ES.2018.23.47.1800617.

Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018

Daniel Golparian  1 , Lisa Rose  2 , Almida Lynam  3 , Aia Mohamed  2 , Beatrice Bercot  4 , Makoto Ohnishi  5 , Brendan Crowley  2   6   7 , Magnus Unemo  1   7
Affiliations

Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018

Daniel Golparian et al. Euro Surveill. 2018 Nov.

Abstract

We describe a multidrug-resistant Neisseria gonorrhoeae urethritis case with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Ireland, August 2018. Whole-genome sequencing showed that the isolate IR72 belongs to the internationally spreading multidrug-resistant ceftriaxone-resistant FC428 clade, initially described in Japan in 2015. IR72 was assigned MSLT ST1903, NG-MAST ST17842 and NG-STAR type 1133, including the ceftriaxone resistance-mediating penA-60.001. Global awareness of spreading ceftriaxone-resistant gonococcal strains that threaten recommended dual therapies is essential.

Keywords: FC428; Ireland; Neisseria gonorrhoeae; azithromycin; ceftriaxone; gonorrhoea; multidrug-resistant; resistance; treatment.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure
Figure
Phylogenetic tree including the whole genome sequence of the ceftriaxone-resistant isolate (IR72), Ireland, August 2018
See this image and copyright information in PMC

References

    1. Nakayama S, Shimuta K, Furubayashi K, Kawahata T, Unemo M, Ohnishi M. New ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain with a novel mosaic penA gene isolated in Japan. Antimicrob Agents Chemother. 2016;60(7):4339-41. 10.1128/AAC.00504-16 - DOI - PMC - PubMed
    1. Lahra MM, Martin I, Demczuk W, Jennison AV, Lee KI, Nakayama SI, et al. Cooperative recognition of internationally disseminated ceftriaxone-resistant Neisseria gonorrhoeae strain. Emerg Infect Dis. 2018;24(4):735-40. 10.3201/eid2404.171873 - DOI - PMC - PubMed
    1. Lefebvre B, Martin I, Demczuk W, Deshaies L, Michaud S, Labbé AC, et al. Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017. Emerg Infect Dis. 2018;24(2):381-3. 10.3201/eid2402.171756 - DOI - PMC - PubMed
    1. Terkelsen D, Tolstrup J, Johnsen CH, Lund O, Larsen HK, Worning P, et al. Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017. Euro Surveill. 2017;22(42):1273. 10.2807/1560-7917.ES.2017.22.42.17-00659 - DOI - PMC - PubMed
    1. Poncin T, Fouere S, Braille A, Camelena F, Agsous M, Bebear C, et al. Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017. Euro Surveill. 2018;23(21):1800264. 10.2807/1560-7917.ES.2018.23.21.1800264 - DOI - PMC - PubMed

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