Evaluation of COLIA1-1997 G/T polymorphism as a related factor to genital prolapse

Abstract

Introduction and hypothesis: Pelvic organ prolapse has a multifactorial etiology. There is increasing evidence that genetic factors greatly impact its development. This study aimed to evaluate the possible relation of the collagenous polymorphism -1997 G/T with genital prolapse in Brazilian women.

Methods: A cohort study of 180 women with stage 0 or I (group A) pelvic organ prolapse disorder and 112 women with stage III or IV (group B) was conducted. Blood DNA was isolated, and the -1997 G/T polymorphism was identified by amplifying a region of the COLIA1 gene starting prior to the protein's coding sequence.

Results: No significant difference in the prevalence of genotypes TG and TT was found between groups (p = 0.67); differences were not found even when patients were grouped by the presence of 0 or ≥ 1 polymorphic alleles (p = 0.46). Age and home birth were found to be independent risk factors for prolapse.

Conclusions: Our study could not find any association between the -1997G/T polymorphism and genital prolapse in Brazilian women.

Keywords: Collagen I A1 gene; Pelvic organ prolapse; Polymorphism; rs1107946; −1997G/T.