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Case Reports
. 2018 Nov/Dec;93(6):874-877.
doi: 10.1590/abd1806-4841.20187290.

Autoimmune progesterone dermatitis manifesting as generalized fixed drug eruption

Juan Eduardo Carrasco-Zuber  1 , Sergio Álvarez-Véliz  2 , Catherina Moll-Manzur  3 , Sergio González-Bombardiere  4
Affiliations
Case Reports

Autoimmune progesterone dermatitis manifesting as generalized fixed drug eruption

Juan Eduardo Carrasco-Zuber et al. An Bras Dermatol. 2018 Nov/Dec.

Abstract

Autoimmune progesterone dermatitis is an uncommon, poorly recognized and under-diagnosed catamenial dermatosis associated with hypersensitivity reactions to progestagens. Most cases manifest as urticaria, eczema or erythema multiforme-like. A 26-year-old woman developed violaceous plaques on the groin and abdomen, 4 days after a spontaneous abortion resolved with uterine curettage. The lesions recurred once monthly at the same sites, mimicking a fixed drug eruption. Although the histopathology was compatible with fixed drug eruption, positive intradermal testing and symptomatic improvement after using oral contraceptive pills gave us a clue to the diagnosis.

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Conflict of interest statement

Conflict of interest: None.

Figures

Figure 1
Figure 1
Sharply demarcated erythematous/violaceous plaques on armpit
Figure 2
Figure 2
Sharply demarcated erythematous/violaceous plaques on abdomen and groin
Figure 3
Figure 3
Inflammatory reaction with mild perivascular infiltration of lymphocytes, some in the papillae, vacuolar alteration in basal keratinocytes, and numerous melanophages, with sparse eosinophils. (Hematoxylin & eosin, x200)
Figure 4
Figure 4
Intradermal test. Erythema and edema 3 minutes after progesterone injection
See this image and copyright information in PMC

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