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. 2019 Mar;26(2):e12472.
doi: 10.1111/xen.12472. Epub 2018 Nov 28.

Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance?

Hayato Iwase  1 , Takayuki Yamamoto  1 , David K C Cooper  1
Affiliations

Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance?

Hayato Iwase et al. Xenotransplantation. 2019 Mar.
No abstract available

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Conflict of interest statement

Conflict of interest

No author declares a conflict of interest.

Figures

Figure 1:
Figure 1:. Changes in serum creatinine in baboons with life-supporting pig kidney grafts (with nephrectomy of the native kidneys at the time of pig kidney transplantation) in (A) B10815, (B) B17315, (C) B17615, (D) B9313.
Examples of spontaneous increases in serum creatinine unrelated to to an immune response, and corrected by fluid administration, are indicated. The most obvious increase was in B10815 on post-transplant day 39. On each occasion, the rapid reduction in creatinine to normal (human) levels was associated solely with i.v. and/or s.c. infusions of normal saline. The normal range of serum creatinine in baboon, human, and pig is 0.6–0.8mg/dL, 0.5–1.4mg/dL, and 0.6–1.6mg/dL, respectively (3). Horizontal arrows indicate when fluid was administered. (*In Figure 1A, the serum creatinine increased to 5.3 on day 78. The biopsy on day 82 was the only case out of 5 that showed any histopathological features of rejection. In Figure 1D, the final increase in serum creatinine was related to systemic infection.)
Figure 1:
Figure 1:. Changes in serum creatinine in baboons with life-supporting pig kidney grafts (with nephrectomy of the native kidneys at the time of pig kidney transplantation) in (A) B10815, (B) B17315, (C) B17615, (D) B9313.
Examples of spontaneous increases in serum creatinine unrelated to to an immune response, and corrected by fluid administration, are indicated. The most obvious increase was in B10815 on post-transplant day 39. On each occasion, the rapid reduction in creatinine to normal (human) levels was associated solely with i.v. and/or s.c. infusions of normal saline. The normal range of serum creatinine in baboon, human, and pig is 0.6–0.8mg/dL, 0.5–1.4mg/dL, and 0.6–1.6mg/dL, respectively (3). Horizontal arrows indicate when fluid was administered. (*In Figure 1A, the serum creatinine increased to 5.3 on day 78. The biopsy on day 82 was the only case out of 5 that showed any histopathological features of rejection. In Figure 1D, the final increase in serum creatinine was related to systemic infection.)
Figure 1:
Figure 1:. Changes in serum creatinine in baboons with life-supporting pig kidney grafts (with nephrectomy of the native kidneys at the time of pig kidney transplantation) in (A) B10815, (B) B17315, (C) B17615, (D) B9313.
Examples of spontaneous increases in serum creatinine unrelated to to an immune response, and corrected by fluid administration, are indicated. The most obvious increase was in B10815 on post-transplant day 39. On each occasion, the rapid reduction in creatinine to normal (human) levels was associated solely with i.v. and/or s.c. infusions of normal saline. The normal range of serum creatinine in baboon, human, and pig is 0.6–0.8mg/dL, 0.5–1.4mg/dL, and 0.6–1.6mg/dL, respectively (3). Horizontal arrows indicate when fluid was administered. (*In Figure 1A, the serum creatinine increased to 5.3 on day 78. The biopsy on day 82 was the only case out of 5 that showed any histopathological features of rejection. In Figure 1D, the final increase in serum creatinine was related to systemic infection.)
Figure 1:
Figure 1:. Changes in serum creatinine in baboons with life-supporting pig kidney grafts (with nephrectomy of the native kidneys at the time of pig kidney transplantation) in (A) B10815, (B) B17315, (C) B17615, (D) B9313.
Examples of spontaneous increases in serum creatinine unrelated to to an immune response, and corrected by fluid administration, are indicated. The most obvious increase was in B10815 on post-transplant day 39. On each occasion, the rapid reduction in creatinine to normal (human) levels was associated solely with i.v. and/or s.c. infusions of normal saline. The normal range of serum creatinine in baboon, human, and pig is 0.6–0.8mg/dL, 0.5–1.4mg/dL, and 0.6–1.6mg/dL, respectively (3). Horizontal arrows indicate when fluid was administered. (*In Figure 1A, the serum creatinine increased to 5.3 on day 78. The biopsy on day 82 was the only case out of 5 that showed any histopathological features of rejection. In Figure 1D, the final increase in serum creatinine was related to systemic infection.)
Figure 2:
Figure 2:. Histological appearance of a renal biopsy taken on day 103 in B9313.
The biopsy was taken at the time when the serum creatinine had increased, and rejection was considered a strong possibility (see Figure 1D). However, no histopathological features of rejection were seen, and the serum creatinine returned to the normal range within 3 days after the i.v. infusion of several hundred milliliters of normal saline.
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