Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2019 Mar;13(2):208-212.
doi: 10.1111/irv.12622. Epub 2018 Dec 17.

Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

Caroline Quinn Pratt  1 , Yuwei Zhu  2 , Carlos G Grijalva  3 , Richard G Wunderink  4 , D Mark Courtney  5 , Grant Waterer  4   6 , Min Z Levine  7 , Stacie Jefferson  7 , Wesley H Self  8 , Derek J Williams  9 , Lynn Finelli  7 , Anna M Bramley  7 , Kathryn M Edwards  10 , Seema Jain  7 , Evan J Anderson  11
Affiliations
Multicenter Study

Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

Caroline Quinn Pratt et al. Influenza Other Respir Viruses. 2019 Mar.

Abstract

Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.

PubMed Disclaimer

References

    1. Commission TJ. Specifications Manual for National Hospital Inpatient Quality Measures Discharges 01‐01‐18 (1Q18) through 06‐30‐18 (2Q18) Version 5.3. http://www.jointcommission.org/specifications_manual_for_national_hospit.... Accessed 04 April 2018, 2018.
    1. Tartof SY, Qian L, Rieg GK, et al. Safety of seasonal influenza vaccination in hospitalized surgical patients: a cohort study. Ann Intern Med. 2016;164(9):593‐599. - PubMed
    1. Muszkat M, Friedman G, Dannenberg HD, et al. Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors. Exp Gerontol. 2003;38(10):1199‐1203. - PubMed
    1. Nath KD, Burel JG, Shankar V, et al. Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2014;9:51‐56. - PMC - PubMed
    1. Song JY, Cheong HJ, Hwang IS, et al. Long‐term immunogenicity of influenza vaccine among the elderly: risk factors for poor immune response and persistence. Vaccine. 2010;28(23):3929‐3935. - PubMed

Publication types

MeSH terms