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. 2018 Nov 26;15(12):2646.
doi: 10.3390/ijerph15122646.

Evaluation of the Association between Gestational Diabetes Mellitus at First Pregnancy and Cancer within 10 Years Postpartum Using National Health Insurance Data in South Korea

Kyu-Tae Han  1 , Geum Joon Cho  2 , Eui Hyeok Kim  3
Affiliations

Evaluation of the Association between Gestational Diabetes Mellitus at First Pregnancy and Cancer within 10 Years Postpartum Using National Health Insurance Data in South Korea

Kyu-Tae Han et al. Int J Environ Res Public Health. .

Abstract

This study aims to evaluate the association between gestational diabetes mellitus (GDM) at first pregnancy and the incidence of cancer within 10 years postpartum. We used customized health information data from the National Health Insurance Corporation (NHIC). This retrospective cohort study included data from women who were not previously diagnosed with diabetes or any kind of malignancy in the National Health Screening Examination through the NHIC during 2002⁻2003, and only women who had their first delivery between 2004 and 2005 was included. Follow-up cancer diagnosis was carried out up until 2015. Among the 102,900 primiparous women, 4970 (4.83%) were diagnosed with GDM. During 10 year total follow-up period, 6569 (6.38%) cases of primary cancer were identified. The incidence of cancer was higher in women with GDM and the most common type of cancer was thyroid cancer, followed by breast cancer. On the basis of survival analysis, we adopted the Cox proportional hazards model and found that GDM was positively associated with cancer, particularly in thyroid cancer (HR: 1.27, 95% CI: 1.054⁻1.532, p = 0.012). However, the incidence of other malignancies (including ovarian and breast cancers) were not significantly associated with GDM, though they did show positive trends. Our findings suggest that GDM is associated with the incidence of cancer, particular thyroid cancer.

Keywords: cancer; diabetes mellitus; gestational diabetes mellitus; thyroid cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The study population in this study. * NHSE; National Health Screening Examination.
See this image and copyright information in PMC

References

    1. Ferrara A. Increasing prevalence of gestational diabetes mellitus: A public health perspective. Diabetes Care. 2007;30:S141–S146. doi: 10.2337/dc07-s206. - DOI - PubMed
    1. Metzger B.E., Buchanan T.A., Coustan D.R., De Leiva A., Dunger D.B., Hadden D.R., Hod M., Kitzmiller J.L., Kjos S.L., Oats J.N. Summary and recommendations of the fifth international workshop-conference on gestational diabetes mellitus. Diabetes Care. 2007;30:S251–S260. doi: 10.2337/dc07-s225. - DOI - PubMed
    1. Moyer V.A. Screening for gestational diabetes mellitus: US Preventive Services Task Force recommendation statement. Ann. Intern. Med. 2014;160:414–420. doi: 10.7326/M13-2905. - DOI - PubMed
    1. Cho G.J., Park J.H., Lee H., Yoo S., Shin S.-A., Oh M.-J. Prepregnancy factors as determinants of the development of diabetes mellitus after first pregnancy. J. Clin. Endocrinol. Metab. 2016;101:2923–2930. - PubMed
    1. Albrecht S.S., Kuklina E.V., Bansil P., Jamieson D.J., Whiteman M.K., Kourtis A.P., Posner S.F., Callaghan W.M. Diabetes trends among delivery hospitalizations in the United States, 1994–2004. Diabetes Care. 2010;33:768–773. doi: 10.2337/dc09-1801. - DOI - PMC - PubMed