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. 2018 Nov 26;16(12):468.
doi: 10.3390/md16120468.

Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66

Chang-Liang An  1   2 , Fan-Dong Kong  3 , Qing-Yun Ma  4 , Qing-Yi Xie  5 , Jing-Zhe Yuan  6 , Li-Man Zhou  7 , Hao-Fu Dai  8 , Zhi-Fang Yu  9 , You-Xing Zhao  10
Affiliations

Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66

Chang-Liang An et al. Mar Drugs. .

Abstract

Five new compounds named asperpenes A-C (1⁻3), 12,13-dedihydroversiol (4), and methyl 6-oxo-3,6-dihydro-2H-pyran-4-carboxylate (5), along with 10 known compounds (6⁻15), were isolated from the fermentation broth of Aspergillus sp. SCS-KFD66 associated with a bivalve mollusk, Sanguinolaria chinensis, collected from Haikou Bay, China. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were unambiguously determined by spectroscopic data, single-crystal X-ray diffraction analysis, and electronic circular dichroism (ECD) spectral analysis, along with quantum ECD calculations. The growth inhibitory activity of the compounds against four pathogenic bacterial (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 6538, Listeria monocytogenes ATCC 1911, and Bacillus subtilis ATCC 6633), their enzyme inhibitory activities against acetylcholinesterase and α-glucosidase, and their DPPH radical scavenging activity were evaluated.

Keywords: Aspergillus sp.; antibacterial activity; marine-derived fungus; secondary metabolites.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of compounds 1–15.
Figure 2
Figure 2
Key COSY (▬) and HMBC (→) correlations of 1–5.
Figure 3
Figure 3
Key ROESY correlations of 1–4.
Figure 4
Figure 4
ORTEP diagrams of 1 and 6.
Figure 5
Figure 5
Comparison of measured and calculated ECD spectra for 1 and 4 and ECD exciton chirality model for 4.
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