[Research progress on anti-inflammatory mechanism of natural sesquiterpenoids]
- PMID: 30486522
- DOI: 10.19540/j.cnki.cjcmm.20180726.013
[Research progress on anti-inflammatory mechanism of natural sesquiterpenoids]
Abstract
Sesquiterpenoid is a kind of compound widely distributed in nature, which has a wide range of biological activities, such as anti-inflammatory, anti-tumor and immunomodulatory activities. This paper would review the anti-inflammatory mechanism of sesquiterpenoid. The mechanism is mainly by inhibiting the activation of nuclear factor (NF-κB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor-α (TNF-α), prostaglandin E₂ (PGE₂), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors. Thereby, the production and release of inflammatory cytokines are reduced to exert anti-inflammatory effect. This review is intended to provide reference for related research.
Keywords: anti-inflammatory; mechanism; research progress; sesquiterpenoid.
Copyright© by the Chinese Pharmaceutical Association.
Conflict of interest statement
The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.
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