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Comment
. 2018 Dec 11;115(50):12556-12558.
doi: 10.1073/pnas.1818287115. Epub 2018 Nov 28.

Alternative pathway to reduced artemisinin susceptibility in Plasmodium falciparum

Ryan C Henrici  1 , Colin J Sutherland  2
Affiliations
Comment

Alternative pathway to reduced artemisinin susceptibility in Plasmodium falciparum

Ryan C Henrici et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Impact of transient ring-stage ART exposure on intraerythrocytic growth of P. falciparum. Parasites expressing certain genetic variants of Coronin (14) and Kelch 13 proteins (8) have increased chance of survival after a brief ring-stage pulse of ART in vitro. Other genes, such as pfap2mu and pfubp1, may also encode variant proteins conferring a similar phenotype but have not yet been fully validated. ART exposure at any other stage of intraerythrocytic development, later than 6 to 8 h postinvasion, is lethal for all genotypes. mut, mutant form; SE Asia, Southeast Asia.
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