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Comment
. 2019 Jan;9(1):10.
doi: 10.1158/2159-8290.CD-ND2018-010. Epub 2018 Nov 28.

A Deep Dive into Immunotherapy Resistance

No authors listed
Comment

A Deep Dive into Immunotherapy Resistance

No authors listed. Cancer Discov. 2019 Jan.

Abstract

Through single-cell RNA sequencing, two groups of researchers offer new insight into the respective roles of CD8+ T cells and tumor cells in driving immunotherapy resistance. Their studies pinpoint two distinct T-cell states, as well as a T-cell exclusion program promoted by tumor cells, that may influence patients' likelihood of response to immune checkpoint blockade.

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