[Secondary osteoporosis. Bone quality deterioration in lifestyle-related disease]

Abstract

Both lifestyle-related disease and ostepoross increase with aging;thus the number of patients with these diseases will increase in future. Because diabetes mellitus, a representative lifestyle-related disease, induces bone fragility due to deterioration of bone quality, if all of the focus is given only to bone mineral density values, we might underestimate fracture risks in the patients. Previous studies have shown that accumulation of advanced glycation end products in bone matrix, abnormal bone microstructure, and dysfunction of bone remodeling with decreased bone formation are involved in the mechanism of bone quality deterioration. However, there are no specific parameters to evaluate bone quality in clinical settings so far. Therefore, it is necessary to find patients with clinical risk factor of fracture and to perform intensive treatments for osteoporosis.