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. 2018 Nov 28;15(12):2687.
doi: 10.3390/ijerph15122687.

Activity of Antioxidant Enzymes and Their Association with Lipid Profile in Mexican People without Cardiovascular Disease: An Analysis of Interactions

Susana Rivera-Mancía  1 , Angélica Saraí Jiménez-Osorio  2 , Omar Noel Medina-Campos  3 , Eloísa Colín-Ramírez  4 , Maite Vallejo  5 , Ariadna Alcántara-Gaspar  6 , Raúl Cartas-Rosado  7 , Jesús Vargas-Barrón  8 , José Pedraza-Chaverri  9
Affiliations

Activity of Antioxidant Enzymes and Their Association with Lipid Profile in Mexican People without Cardiovascular Disease: An Analysis of Interactions

Susana Rivera-Mancía et al. Int J Environ Res Public Health. .

Abstract

Dyslipidemia and oxidative stress are both considered to be factors involved in cardiovascular disease; however, the relationship between them has been little explored. In this work, we studied the association between the lipid profile and the activity of antioxidant enzymes such as paraoxonase-1 (PON1), superoxide dismutase 1 (SOD1), ceruloplasmin, and catalase, as well as total antioxidant capacity (the ferric-reducing ability of plasma (FRAP)), in 626 volunteers without cardiovascular disease. Their lipid profile was evaluated, and they were classified as having or not having high triglycerides (↑TG), high low-density cholesterol (↑LDLC), and low high-density cholesterol (↓HDLC), resulting in eight groups: Without dyslipidemia, ↑TG, ↑LDLC, ↓HDLC, ↑TG↑LDLC, ↑TG↓HDLC, ↑LDLC↓HDLC, and ↑TG↑LDLC↓HDLC. When comparisons by group were made, no significant differences in the activity of antioxidant enzymes were obtained. However, the linear regression analysis considering the potential interactions between ↑TG, ↑LDLC, and ↓HDLC suggested a triple interaction between the three lipid profile alterations on the activity of PON1 and a double interaction between ↑TG and ↑LDLC on ferroxidase-ceruloplasmin activity. The analysis presented in this work showed an association between the lipid profile and antioxidant-enzyme activity and highlighted the importance of considering the interactions between the components of a phenomenon instead of studying them individually. Longitudinal studies are needed to elucidate the nature of these associations.

Keywords: antioxidant activity; cardiovascular risk; catalase; ceruloplasmin; dyslipidemia; ferric-reducing ability of plasma; paraoxonase; superoxide dismutase.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Flow diagram of participants. This study included volunteers from the Tlalpan 2020 cohort. In addition to the criteria of the cohort, those participants taking lipid-lowering medication were excluded from this study.
See this image and copyright information in PMC

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