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Comment
. 2018 Dec;15(12):1095-1097.
doi: 10.1038/s41423-018-0188-7. Epub 2018 Nov 28.

Warm up, cool down, and tearing apart in NK cell memory

Lawrence Shih-Hsin Wu  1 , Jiu-Yao Wang  2
Affiliations
Comment

Warm up, cool down, and tearing apart in NK cell memory

Lawrence Shih-Hsin Wu et al. Cell Mol Immunol. 2018 Dec.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Chromatin remodeling (alterations in the differentially accessible regions) in the process of NK cell transitioning from naïve to long-lived stages. A majority of these epigenetic changes occurred by day14 after infection and minimal changes continued to occur as the differentiating NK cells transitioned between days 14 and 35. While many of these changing regions returned to the naïve levels, a sizable portion of these regions (at least~30%) remained at a substantially altered state of accessibility. The greatest global changes occurred during the first week of viral infection and relatively little epigenetic modulation occurred between days 14 and 35
See this image and copyright information in PMC

Comment on

  • Epigenetic control of innate and adaptive immune memory.
    Lau CM, Adams NM, Geary CD, Weizman OE, Rapp M, Pritykin Y, Leslie CS, Sun JC. Lau CM, et al. Nat Immunol. 2018 Sep;19(9):963-972. doi: 10.1038/s41590-018-0176-1. Epub 2018 Aug 6. Nat Immunol. 2018. PMID: 30082830 Free PMC article.

References

    1. Butz EA, Bevan MJ. Massive expansion of antigen-specific CD8+T cells during an acute virus infection. Immunity. 1998;8:167–175. doi: 10.1016/S1074-7613(00)80469-0. - DOI - PMC - PubMed
    1. Murali-Krishna K, et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity. 1998;8:177–187. doi: 10.1016/S1074-7613(00)80470-7. - DOI - PubMed
    1. Williams MA, Bevan MJ. Effector and memory CTL differentiation. Annu. Rev. Immunol. 2007;25:171–192. doi: 10.1146/annurev.immunol.25.022106.141548. - DOI - PubMed
    1. Netea MG, et al. Trained immunity: a program of innate immune memory in health and disease. Science. 2016;352:aaf1098. doi: 10.1126/science.aaf1098. - DOI - PMC - PubMed
    1. Saeed S, et al. Epigenetic programming of monocyteto- macrophage differentiation and trained innate immunity. Science. 2014;345:1251086. doi: 10.1126/science.1251086. - DOI - PMC - PubMed