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. 2018 Nov 16;10(11):348-353.
doi: 10.4253/wjge.v10.i11.348.

Submucosal injection of platelet-rich plasma in endoscopic resection of large sessile lesions

Vicente Lorenzo-Zúñiga  1 , Vicente Moreno de Vega  2 , Ramón Bartolí  2 , Ingrid Marín  2 , Noemí Caballero  2 , Ignacio Bon  2 , Jaume Boix  2
Affiliations

Submucosal injection of platelet-rich plasma in endoscopic resection of large sessile lesions

Vicente Lorenzo-Zúñiga et al. World J Gastrointest Endosc. .

Abstract

Aim: To prospectively evaluate the efficacy of submucosal injection of platelet-rich plasma (PRP) on endoscopic resection of large sessile lesions.

Methods: Eleven patients were submitted to endoscopic mucosal resection (EMR) with prior injection of PRP, obtained at the time of endoscopy. Patients were followed during 1 mo. The incidence of adverse events (delayed bleeding or perforation) and the percentage of mucosal healing (MHR) after 4 wk were registered.

Results: EMR was performed in 11 lesions (46.4 mm ± 4 mm, range 40-70 mm). Delayed bleeding or perforation was not observed in any patient. Mean ulcerated area at baseline was 22.7 cm2 ± 11.7 cm2 whereas at week 4 were 2.9 cm2 ± 1.5 cm2. Patients treated with PRP showed a very high MHR after 4 wk (87.5%).

Conclusion: PRP is an easy-to-obtain solution with proven and favourable biological activities that could be used in advanced endoscopic resection.

Keywords: Endoscopic mucosal resection; Large lesions; Platelet-rich plasma; Submucosal injection.

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Conflict of interest statement

Conflict-of-interest statement: The authors of this manuscript having no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Patient flow-chart. EMR: Endoscopic mucosal resection; PRP: Platelet-rich plasma.
Figure 2
Figure 2
Preparation of platelet-rich plasma. A: Olin-1 Kit; B: Centrifugation of peripheral blood; C: PRP; D: Activation of PRP. PRP: Platelet-rich plasma.
Figure 3
Figure 3
Mean ulcerated area and mucosal healing rate were calculated by the use of ImageJ public software (Image Processing and Analysis in Java. https://imagej.nih.gov/ij).
Figure 4
Figure 4
Mucosal healing after endoscopic resection in two patients treated with submucosal injection of platelet-rich plasma at baseline and after 4 wk. A: Patient 1 at baseline; B: Patient 1 at week 4; C: Patient 2 at baseline; D: Patient 2 at week 4.
See this image and copyright information in PMC

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